Aging impairs reverse remodeling and recovery of ventricular function after isoproterenol-induced cardiomyopathy

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• dc.contributor.author Yáñez Bisbe, Laia, 1993-
• dc.contributor.author Garcia-Elias Heras, Anna
• dc.contributor.author Tajes Orduña, Marta
• dc.contributor.author Almendros, Isaac
• dc.contributor.author Rodríguez-Sinovas, Antonio
• dc.contributor.author Inserte, Javier
• dc.contributor.author Ruiz-Meana, Marisol
• dc.contributor.author Farré, Ramon
• dc.contributor.author Farré López, Núria
• dc.contributor.author Benito Villabriga, Begoña
• dc.date.accessioned 2022-09-23T06:23:32Z
• dc.date.available 2022-09-23T06:23:32Z
• dc.date.issued 2022
• dc.description.abstract Information about heart failure with reduced ejection fraction (HFrEF) in women and the potential effects of aging in the female heart is scarce. We investigated the vulnerability to develop HFrEF in female elderly mice compared to young animals, as well as potential differences in reverse remodeling. First, HF was induced by isoproterenol infusion (30 mg/kg/day, 28 days) in young (10-week-old) and elderly (22-month-old) female mice. In a second set of animals, mice underwent isoproterenol infusion followed by no treatment during 28 additional days. Cardiac remodeling was assessed by echocardiography, histology and gene expression of collagen-I and collagen-III. Following isoproterenol infusion, elderly mice developed similar HFrEF features compared to young animals, except for greater cell hypertrophy and tissue fibrosis. After beta-adrenergic withdrawal, young female mice experienced complete reversal of the HFrEF phenotype. Conversely, reversed remodeling was impaired in elderly animals, with no significant recovery of LV ejection fraction, cardiomyocyte hypertrophy and collagen deposition. In conclusion, chronic isoproterenol infusion is a valid HF model for elderly and young female mice and induces a similar HF phenotype in both. Elderly animals, unlike young, show impaired reverse remodeling, with persistent tissue fibrosis and cardiac dysfunction even after beta-adrenergic withdrawal.
• dc.format.mimetype application/pdf
• dc.identifier.citation Yáñez-Bisbe L, Garcia-Elias A, Tajes M, Almendros I, Rodríguez-Sinovas A, Inserte J, Ruiz-Meana M, Farré R, Farré N, Benito B. Aging impairs reverse remodeling and recovery of ventricular function after isoproterenol-induced cardiomyopathy. Int J Mol Sci. 2021 Dec 24;23(1):174. DOI: 10.3390/ijms23010174
• dc.identifier.doi http://dx.doi.org/10.3390/ijms23010174
• dc.identifier.issn 1422-0067
• dc.identifier.uri http://hdl.handle.net/10230/54169
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Int J Mol Sci. 2021 Dec 24;23(1):174
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword HFrEF
• dc.subject.keyword Ageing
• dc.subject.keyword Cardiac remodeling
• dc.subject.keyword Female animals
• dc.subject.keyword Heart failure
• dc.subject.keyword Reverse remodeling
• dc.subject.keyword Ventricular dysfunction
• dc.title Aging impairs reverse remodeling and recovery of ventricular function after isoproterenol-induced cardiomyopathy
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion