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Enhancing the sensitivity of memory tests: reference data for the free and cued selective reminding test and the logical memory task from cognitively healthy subjects with normal alzheimer's disease cerebrospinal fluid biomarker levels

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dc.contributor.author Brugulat Serrat, Anna, 1986-
dc.contributor.author Cañas-Martínez, Alba
dc.contributor.author Canals-Gispert, Lidia
dc.contributor.author Marne, Paula
dc.contributor.author Gramunt Fombuena, Nina
dc.contributor.author Suárez-Calvet, Marc
dc.contributor.author Arenaza Urquijo, Eider M.
dc.contributor.author Grau-Rivera, Oriol
dc.contributor.author González de Echávarri, José Maria
dc.contributor.author Minguillón, Carolina
dc.contributor.author Fauria, Karine
dc.contributor.author Kollmorgen, Gwendlyn
dc.contributor.author Suridjan, Ivonne
dc.contributor.author Zetterberg, Henrik
dc.contributor.author Blennow, Kaj
dc.contributor.author Gispert López, Juan Domingo
dc.contributor.author Molinuevo, José Luis
dc.contributor.author Sánchez Benavides, Gonzalo
dc.contributor.author ALFA Study
dc.date.accessioned 2022-07-14T07:13:08Z
dc.date.available 2022-07-14T07:13:08Z
dc.date.issued 2021
dc.identifier.citation Brugulat-Serrat A, Cañas-Martínez A, Canals-Gispert L, Marne P, Gramunt N, Milà-Alomà M, et al. Enhancing the sensitivity of memory tests: reference data for the free and cued selective reminding test and the logical memory task from cognitively healthy subjects with normal alzheimer's disease cerebrospinal fluid biomarker levels. J Alzheimers Dis. 2021; 84(1): 119-28. DOI: 10.3233/JAD-210640
dc.identifier.issn 1387-2877
dc.identifier.uri http://hdl.handle.net/10230/53733
dc.description.abstract Background: Cognitive performance of a given individual should be interpreted in the context of reference standards obtained in cognitively healthy populations. Recent evidence has shown that removing asymptomatic individuals with biomarker evidence of Alzheimer's disease pathology from normative samples increases the sensitivity of norms to detect memory impairments. These kind of norms may be useful for defining subtle cognitive decline, the transitional cognitive decline between normal cognition and mild cognitive impairment. Objective: the present study aims to provide norms for the Free and Cued Selective Reminding Test (FCSRT) and the Logical Memory subtest of the Wechsler Memory Scale-IV in a sample of individuals aged 50-70 years with normal levels of amyloid-β and tau cerebrospinal fluid (CSF) biomarkers. Methods: the sample was composed of 248 individuals from the ALFA+ study with negative amyloid-β and tau CSF biomarker levels. Regression-based norms were developed, including adjustments for age, education, and sex when applicable. Results: we found that education was associated with the performance in all the variables of both tests while age had a marginal effect only in the delayed free recall of the FCSRT. Sex was also related to the performance in the FCSRT, with women outperforming men. Equations to calculate z-scores and normative percentile tables were created. As compared with previously published norms the reference data presented were more sensitive but less specific, as expected. Conclusion: the use of the norms provided in this work, in combination with the already published conventional norms, may contribute to detecting subtle memory impairment.
dc.description.sponsorship The research leading to these results has received funding from “la Caixa” Foundation (LCF/PR/GN17/10300004) and the Alzheimer’s Association and an international anonymous charity foundation through the TriBEKa Imaging Platform project (TriBEKa-17-519007). Additional support has been received from the Universities and Research Secretariat, Ministry of Business and Knowledge of the Catalan Government under the grant no. 2017-SGR-892. MS-C received funding from the European Union’s Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie action grant agreement No 752310, and currently receives funding from the Spanish Ministry of Science, Innovation and Universities (Juan de la Cierva Programme grant IJC2018-037478-I). EMA-U is supported by the Spanish Ministry of Science, Innovation and Universities - Spanish State Research Agency (RYC2018-026053-I) and is recipient of the Alzheimer’s Association Research Grant (AARC 2019-AARG 644641). OG-R is supported by the Spanish Ministry of Science, Innovation and Universities (FJCI-2017-33437). JDG holds a ‘Ramón y Cajal’ fellowship (RYC-2013-13054).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IOS Press
dc.rights ISSN 1387-2877 © 2021 – Brugulat Serrat, A. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0) http://creativecommons.org/licenses/by-nc/4.0/.
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Enhancing the sensitivity of memory tests: reference data for the free and cued selective reminding test and the logical memory task from cognitively healthy subjects with normal alzheimer's disease cerebrospinal fluid biomarker levels
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3233/JAD-210640
dc.subject.keyword Alzheimer’s disease
dc.subject.keyword Amyloid
dc.subject.keyword Biomarkers
dc.subject.keyword Cognition
dc.subject.keyword Memory
dc.subject.keyword Norms
dc.subject.keyword Sex
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/752310
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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