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Urinary tartaric acid, a biomarker of wine intake, correlates with lower total and LDL cholesterol

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dc.contributor.author Domínguez-López, Inés
dc.contributor.author Parilli-Moser, Isabella
dc.contributor.author Arancibia-Riveros, Camila
dc.contributor.author Tresserra-Rimbau, Anna
dc.contributor.author Martínez-González, Miguel A.
dc.contributor.author Ortega-Azorín, Carolina
dc.contributor.author Salas-Salvadó, Jordi
dc.contributor.author Castañer, Olga
dc.contributor.author Lapetra, José
dc.contributor.author Arós, Fernando
dc.contributor.author Fiol, Miquel
dc.contributor.author Serra-Majem, Luis
dc.contributor.author Pinto, Xavier
dc.contributor.author Gómez-Gracia, Enrique
dc.contributor.author Ros, Emilio
dc.contributor.author Lamuela-Raventós, Rosa M.
dc.contributor.author Estruch, Ramón
dc.date.accessioned 2022-07-05T06:24:06Z
dc.date.available 2022-07-05T06:24:06Z
dc.date.issued 2021
dc.identifier.citation Domínguez-López I, Parilli-Moser I, Arancibia-Riveros C, Tresserra-Rimbau A, Martínez-González MA, et al. Urinary tartaric acid, a biomarker of wine intake, correlates with lower total and LDL colesterol. Nutrients. 2021 Aug 22; 13(8): 2883. DOI: 10.3390/nu13082883
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/53675
dc.description.abstract Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevención con Dieta Mediterránea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 μg/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (-3.13 μg/mg (-5.54, -0.71), p-value = 0.016 and -3.03 μg/mg (-5.62, -0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2021 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). This article has been cited by other articles in PMC. Articles from Nutrients are provided here courtesy of Multidisciplinary Digital Publishing Institute (MDPI)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Urinary tartaric acid, a biomarker of wine intake, correlates with lower total and LDL cholesterol
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu13082883
dc.subject.keyword Mediterranean diet
dc.subject.keyword PREDIMED
dc.subject.keyword Biomarkers
dc.subject.keyword Body fat
dc.subject.keyword Cardiovascular risk
dc.subject.keyword Lipid profile
dc.subject.keyword Menopause
dc.subject.keyword Polyphenols
dc.subject.keyword Tartaric acid
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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