Urinary tartaric acid, a biomarker of wine intake, correlates with lower total and LDL cholesterol

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• dc.contributor.author Domínguez-López, Inés
• dc.contributor.author Parilli-Moser, Isabella
• dc.contributor.author Arancibia-Riveros, Camila
• dc.contributor.author Tresserra-Rimbau, Anna
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Ortega-Azorín, Carolina
• dc.contributor.author Salas-Salvadó, Jordi
• dc.contributor.author Castañer, Olga
• dc.contributor.author Lapetra, José
• dc.contributor.author Arós, Fernando
• dc.contributor.author Fiol, Miquel
• dc.contributor.author Serra-Majem, Luis
• dc.contributor.author Pinto, Xavier
• dc.contributor.author Gómez-Gracia, Enrique
• dc.contributor.author Ros, Emilio
• dc.contributor.author Lamuela-Raventós, Rosa M.
• dc.contributor.author Estruch, Ramón
• dc.date.accessioned 2022-07-05T06:24:06Z
• dc.date.available 2022-07-05T06:24:06Z
• dc.date.issued 2021
• dc.description.abstract Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevención con Dieta Mediterránea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 μg/mg (95% confidence interval (CI): 0.01, 0.01), p-value < 0.001). Total and low-density lipoprotein (LDL) cholesterol were inversely correlated with urinary tartaric acid (-3.13 μg/mg (-5.54, -0.71), p-value = 0.016 and -3.03 μg/mg (-5.62, -0.42), p-value = 0.027, respectively), whereas other biochemical and anthropometric variables were unrelated. The results suggest that wine consumption may have a positive effect on cardiovascular health in postmenopausal women, underpinning its nutraceutical properties.
• dc.format.mimetype application/pdf
• dc.identifier.citation Domínguez-López I, Parilli-Moser I, Arancibia-Riveros C, Tresserra-Rimbau A, Martínez-González MA, et al. Urinary tartaric acid, a biomarker of wine intake, correlates with lower total and LDL colesterol. Nutrients. 2021 Aug 22; 13(8): 2883. DOI: 10.3390/nu13082883
• dc.identifier.doi http://dx.doi.org/10.3390/nu13082883
• dc.identifier.issn 2072-6643
• dc.identifier.uri http://hdl.handle.net/10230/53675
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2021 by the authors.Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). This article has been cited by other articles in PMC. Articles from Nutrients are provided here courtesy of Multidisciplinary Digital Publishing Institute (MDPI)
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword PREDIMED
• dc.subject.keyword Biomarkers
• dc.subject.keyword Body fat
• dc.subject.keyword Cardiovascular risk
• dc.subject.keyword Lipid profile
• dc.subject.keyword Menopause
• dc.subject.keyword Polyphenols
• dc.subject.keyword Tartaric acid
• dc.title Urinary tartaric acid, a biomarker of wine intake, correlates with lower total and LDL cholesterol
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion