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Ferulic acid metabolites attenuate LPS-induced inflammatory response in enterocyte-like cells

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dc.contributor.author Serreli, Gabriele
dc.contributor.author Naitza, Micaela Rita
dc.contributor.author Zodio, Sonia
dc.contributor.author Leoni, Vera Piera
dc.contributor.author Spada, Martina
dc.contributor.author Melis, Maria Paola
dc.contributor.author Boronat Rigol, Anna, 1990-
dc.contributor.author Deiana, Monica
dc.date.accessioned 2022-07-05T06:23:57Z
dc.date.available 2022-07-05T06:23:57Z
dc.date.issued 2021
dc.identifier.citation Serreli G, Naitza MR, Zodio S, Leoni VP, Spada M, Melis MP, et al. Ferulic acid metabolites attenuate LPS-induced inflammatory response in enterocyte-like cells. Nutrients. 2021 Sep 10; 13(9): 3152. DOI: 10.3390/nu13093152
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/53673
dc.description.abstract Ferulic acid (FA) is a polyphenol pertaining to the class of hydroxycinnamic acids present in numerous foods of a plant origin. Its dietary consumption leads to the formation of several phase I and II metabolites in vivo, which represent the largest amount of ferulates in the circulation and in the intestine in comparison with FA itself. In this work, we evaluated their efficacy against the proinflammatory effects induced by lipopolysaccharide (LPS) in intestinal Caco-2 cell monolayers, as well as the mechanisms underlying their protective action. LPS-induced overexpression of proinflammatory enzymes such as inducible nitric oxide synthase (iNOS) and the consequent hyperproduction of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) were limited by physiological relevant concentrations (1 µM) of FA, its derivatives isoferulic acid (IFA) and dihydroferulic acid (DHFA), and their glucuronidated and sulfated metabolites, which acted upstream by limiting the activation of MAPK p38 and ERK and of Akt kinase, thus decreasing the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ĸB) translocation into the nucleus. Furthermore, the compounds were found to promote the expression of Nrf2, which may have contributed to the downregulation of NF-ĸB activity. The overall data show that phase I/II metabolites retain the efficacy of their dietary free form in contrasting inflammatory response.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.title Ferulic acid metabolites attenuate LPS-induced inflammatory response in enterocyte-like cells
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu13093152
dc.identifier.doi http://creativecommons.org/licenses/by/4.0/
dc.subject.keyword MAP kinases
dc.subject.keyword Inflammation
dc.subject.keyword Intestinal cells
dc.subject.keyword Lipopolysaccharide
dc.subject.keyword Metabolites
dc.subject.keyword Nitric oxide
dc.subject.keyword Nitric oxide synthase
dc.subject.keyword Polyphenols
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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