Ferulic acid metabolites attenuate LPS-induced inflammatory response in enterocyte-like cells

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• dc.contributor.author Serreli, Gabriele
• dc.contributor.author Naitza, Micaela Rita
• dc.contributor.author Zodio, Sonia
• dc.contributor.author Leoni, Vera Piera
• dc.contributor.author Spada, Martina
• dc.contributor.author Melis, Maria Paola
• dc.contributor.author Boronat Rigol, Anna, 1990-
• dc.contributor.author Deiana, Monica
• dc.date.accessioned 2022-07-05T06:23:57Z
• dc.date.available 2022-07-05T06:23:57Z
• dc.date.issued 2021
• dc.description.abstract Ferulic acid (FA) is a polyphenol pertaining to the class of hydroxycinnamic acids present in numerous foods of a plant origin. Its dietary consumption leads to the formation of several phase I and II metabolites in vivo, which represent the largest amount of ferulates in the circulation and in the intestine in comparison with FA itself. In this work, we evaluated their efficacy against the proinflammatory effects induced by lipopolysaccharide (LPS) in intestinal Caco-2 cell monolayers, as well as the mechanisms underlying their protective action. LPS-induced overexpression of proinflammatory enzymes such as inducible nitric oxide synthase (iNOS) and the consequent hyperproduction of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) were limited by physiological relevant concentrations (1 µM) of FA, its derivatives isoferulic acid (IFA) and dihydroferulic acid (DHFA), and their glucuronidated and sulfated metabolites, which acted upstream by limiting the activation of MAPK p38 and ERK and of Akt kinase, thus decreasing the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-ĸB) translocation into the nucleus. Furthermore, the compounds were found to promote the expression of Nrf2, which may have contributed to the downregulation of NF-ĸB activity. The overall data show that phase I/II metabolites retain the efficacy of their dietary free form in contrasting inflammatory response.
• dc.format.mimetype application/pdf
• dc.identifier.citation Serreli G, Naitza MR, Zodio S, Leoni VP, Spada M, Melis MP, et al. Ferulic acid metabolites attenuate LPS-induced inflammatory response in enterocyte-like cells. Nutrients. 2021 Sep 10; 13(9): 3152. DOI: 10.3390/nu13093152
• dc.identifier.doi http://dx.doi.org/10.3390/nu13093152
• dc.identifier.doi http://creativecommons.org/licenses/by/4.0/
• dc.identifier.issn 2072-6643
• dc.identifier.uri http://hdl.handle.net/10230/53673
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword MAP kinases
• dc.subject.keyword Inflammation
• dc.subject.keyword Intestinal cells
• dc.subject.keyword Lipopolysaccharide
• dc.subject.keyword Metabolites
• dc.subject.keyword Nitric oxide
• dc.subject.keyword Nitric oxide synthase
• dc.subject.keyword Polyphenols
• dc.title Ferulic acid metabolites attenuate LPS-induced inflammatory response in enterocyte-like cells
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion