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Systemic profiles of microRNAs, redox balance, and inflammation in lung

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dc.contributor.author Qin, Liyun
dc.contributor.author Guitart, Maria
dc.contributor.author Curull Serrano, Víctor
dc.contributor.author Sánchez-Font, Albert
dc.contributor.author Duran, Xavier
dc.contributor.author Tang, Jun
dc.contributor.author Admetlló Papiol, Mireia
dc.contributor.author Barreiro Portela, Esther
dc.date.accessioned 2022-05-20T06:49:19Z
dc.date.available 2022-05-20T06:49:19Z
dc.date.issued 2021
dc.identifier.citation Qin L, Guitart M, Curull V, Sánchez-Font A, Duran X, Tang J, et al. Systemic profiles of microRNAs, redox balance, and inflammation in lung cancer patients: influence of COPD. Biomedicines. 2021 Sep 29; 9(10): 1347. DOI: 10.3390/biomedicines9101347
dc.identifier.issn 2227-9059
dc.identifier.uri http://hdl.handle.net/10230/53188
dc.description.abstract Lung cancer (LC) risk increases in patients with chronic respiratory diseases (COPD). MicroRNAs and redox imbalance are involved in lung tumorigenesis in COPD patients. Whether systemic alterations of those events may also take place in LC patients remains unknown. Our objectives were to assess the plasma levels of microRNAs, redox balance, and cytokines in LC patients with/without COPD. MicroRNAs (RT-PCR) involved in LC, oxidized DNA, MDA-protein adducts, GSH, TEAC, VEGF, and TGF-beta (ELISA) were quantified in plasma samples from non-LC controls (n = 45), LC-only patients (n = 32), and LC-COPD patients (n = 91). In LC-COPD patients compared to controls and LC-only, MDA-protein adduct levels increased, while those of GSH decreased, and two patterns of plasma microRNA were detected. In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls. Correlations were found between clinical and biological variables. A differential expression profile of microRNAs was detected in patients with LC. Moreover, in LC patients with COPD, plasma oxidative stress levels increased, whereas those of GSH declined. Systemic oxidative and antioxidant markers are differentially expressed in LC patients with respiratory diseases, thus implying its contribution to the pathogenesis of tumorigenesis in these patients.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Systemic profiles of microRNAs, redox balance, and inflammation in lung
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/biomedicines9101347
dc.subject.keyword GSH
dc.subject.keyword LC and COPD
dc.subject.keyword Associations between clinical and biological variables
dc.subject.keyword Inflammatory cytokines
dc.subject.keyword MicroRNAs
dc.subject.keyword Prooxidants and antioxidants
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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