Systemic profiles of microRNAs, redox balance, and inflammation in lung
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Qin, Liyun
- dc.contributor.author Guitart, Maria
- dc.contributor.author Curull Serrano, Víctor
- dc.contributor.author Sánchez-Font, Albert
- dc.contributor.author Duran, Xavier
- dc.contributor.author Tang, Jun
- dc.contributor.author Admetlló Papiol, Mireia
- dc.contributor.author Barreiro Portela, Esther
- dc.date.accessioned 2022-05-20T06:49:19Z
- dc.date.available 2022-05-20T06:49:19Z
- dc.date.issued 2021
- dc.description.abstract Lung cancer (LC) risk increases in patients with chronic respiratory diseases (COPD). MicroRNAs and redox imbalance are involved in lung tumorigenesis in COPD patients. Whether systemic alterations of those events may also take place in LC patients remains unknown. Our objectives were to assess the plasma levels of microRNAs, redox balance, and cytokines in LC patients with/without COPD. MicroRNAs (RT-PCR) involved in LC, oxidized DNA, MDA-protein adducts, GSH, TEAC, VEGF, and TGF-beta (ELISA) were quantified in plasma samples from non-LC controls (n = 45), LC-only patients (n = 32), and LC-COPD patients (n = 91). In LC-COPD patients compared to controls and LC-only, MDA-protein adduct levels increased, while those of GSH decreased, and two patterns of plasma microRNA were detected. In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls. Correlations were found between clinical and biological variables. A differential expression profile of microRNAs was detected in patients with LC. Moreover, in LC patients with COPD, plasma oxidative stress levels increased, whereas those of GSH declined. Systemic oxidative and antioxidant markers are differentially expressed in LC patients with respiratory diseases, thus implying its contribution to the pathogenesis of tumorigenesis in these patients.
- dc.format.mimetype application/pdf
- dc.identifier.citation Qin L, Guitart M, Curull V, Sánchez-Font A, Duran X, Tang J, et al. Systemic profiles of microRNAs, redox balance, and inflammation in lung cancer patients: influence of COPD. Biomedicines. 2021 Sep 29; 9(10): 1347. DOI: 10.3390/biomedicines9101347
- dc.identifier.doi http://dx.doi.org/10.3390/biomedicines9101347
- dc.identifier.issn 2227-9059
- dc.identifier.uri http://hdl.handle.net/10230/53188
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword GSH
- dc.subject.keyword LC and COPD
- dc.subject.keyword Associations between clinical and biological variables
- dc.subject.keyword Inflammatory cytokines
- dc.subject.keyword MicroRNAs
- dc.subject.keyword Prooxidants and antioxidants
- dc.title Systemic profiles of microRNAs, redox balance, and inflammation in lung
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion