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Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study

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dc.contributor.author Wang, Gang
dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author Abellan, Alicia
dc.contributor.author García Aymerich, Judith
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Melén, Erik
dc.date.accessioned 2022-05-19T05:52:52Z
dc.date.available 2022-05-19T05:52:52Z
dc.date.issued 2021
dc.identifier.citation Wang G, Hallberg J, Charalampopoulos D, Casas Sanahuja M, Breyer-Kohansal R, Langhammer A et al. Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study. ERJ Open Res. 2021 Dec 6;7(4):00457-2021. DOI: 10.1183/23120541.00457-2021
dc.identifier.issn 2312-0541
dc.identifier.uri http://hdl.handle.net/10230/53154
dc.description.abstract Background: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts. Methods: We studied 49 334 participants from 14 population-based cohorts in different age groups (≤10, >10-15, >15-20, >20-25 years, and overall, 5-25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ≥LLN, and FVC z-score <LLN. Results: The prevalence of obstructive and restrictive phenotypes varied from 3.2-10.9% and 1.8-7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14-3.04), preterm birth (aOR=1.84, 1.27-2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01-1.35) and family history of asthma (aOR=1.44, 95% CI 1.25-1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5-25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03-1.06 and aOR=0.81, 95% CI 0.78-0.85, per kg·m-2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05-1.46). Conclusion: Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
dc.description.sponsorship The project received funding from the European Union's Horizon 2020 research and innovation programme (LIFECYCLE, grant agreement number 733206, 2016; EUCAN-Connect grant agreement number 824989; and ATHLETE, grant agreement number 874583). The researchers are independent from the funders. The study sponsors had no role in the study design, data analysis, interpretation of data, or writing of this report. Consulting fees received for an opponent PhD defence committee at Copenhagen University, outside the submitted work.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.relation.ispartof ERJ Open Res. 2021 Dec 6;7(4):00457-2021
dc.rights © The authors 2021. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1183/23120541.00457-2021
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/824989
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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