Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study

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  • dc.contributor.author Wang, Gang
  • dc.contributor.author Casas Sanahuja, Maribel
  • dc.contributor.author Abellan, Alicia
  • dc.contributor.author García Aymerich, Judith
  • dc.contributor.author Sunyer Deu, Jordi
  • dc.contributor.author Melén, Erik
  • dc.date.accessioned 2022-05-19T05:52:52Z
  • dc.date.available 2022-05-19T05:52:52Z
  • dc.date.issued 2021
  • dc.description.abstract Background: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts. Methods: We studied 49 334 participants from 14 population-based cohorts in different age groups (≤10, >10-15, >15-20, >20-25 years, and overall, 5-25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV1/FVC z-score ≥LLN, and FVC z-score <LLN. Results: The prevalence of obstructive and restrictive phenotypes varied from 3.2-10.9% and 1.8-7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14-3.04), preterm birth (aOR=1.84, 1.27-2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01-1.35) and family history of asthma (aOR=1.44, 95% CI 1.25-1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5-25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03-1.06 and aOR=0.81, 95% CI 0.78-0.85, per kg·m-2 increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05-1.46). Conclusion: Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
  • dc.description.sponsorship The project received funding from the European Union's Horizon 2020 research and innovation programme (LIFECYCLE, grant agreement number 733206, 2016; EUCAN-Connect grant agreement number 824989; and ATHLETE, grant agreement number 874583). The researchers are independent from the funders. The study sponsors had no role in the study design, data analysis, interpretation of data, or writing of this report. Consulting fees received for an opponent PhD defence committee at Copenhagen University, outside the submitted work.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Wang G, Hallberg J, Charalampopoulos D, Casas Sanahuja M, Breyer-Kohansal R, Langhammer A et al. Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study. ERJ Open Res. 2021 Dec 6;7(4):00457-2021. DOI: 10.1183/23120541.00457-2021
  • dc.identifier.doi http://dx.doi.org/10.1183/23120541.00457-2021
  • dc.identifier.issn 2312-0541
  • dc.identifier.uri http://hdl.handle.net/10230/53154
  • dc.language.iso eng
  • dc.publisher European Respiratory Society
  • dc.relation.ispartof ERJ Open Res. 2021 Dec 6;7(4):00457-2021
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/824989
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
  • dc.rights © The authors 2021. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.title Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

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