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5-methylcytosine and 5-hydroxymethylcytosine signatures underlying pediatric cancers

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dc.contributor.author Jhanwar, Shalu, 1986-
dc.contributor.author Deogade, Ajinkya, 1989-
dc.date.accessioned 2022-04-27T10:58:07Z
dc.date.available 2022-04-27T10:58:07Z
dc.date.issued 2019
dc.identifier.citation Jhanwar S, Deogade A. 5-methylcytosine and 5-hydroxymethylcytosine signatures underlying pediatric cancers. Epigenomes. 2019 May 9;3(2):9. DOI:10.3390/epigenomes3020009
dc.identifier.issn 2075-4655
dc.identifier.uri http://hdl.handle.net/10230/52915
dc.description.abstract In addition to the genetic variations, recent evidence has shown that DNA methylation of both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) underlies the pathogenesis of pediatric cancer. Given the high mortality rate, there is an urgent need to study the mechanisms contributing to the pathogenicity of pediatric cancer. Over the past decades, next-generation sequencing (NGS) has enabled us to perform genome-wide screening to study the complex regulatory mechanisms of 5mC and 5hmC underlying pediatric tumorigenesis. To shed light on recent developments on pediatric cancer predisposition and tumor progression, here we discuss the role of both genome-wide and locus-specific dysregulation of 5mC and 5hmC in hematopoiesis malignancy and neuroblastoma, the most common types of pediatric cancer, together with their therapeutic potential.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.uri http://creativecommons.org/licenses/by/4.0/
dc.rights © 2019 by Shalu Jhanwar and Ajinkya Deogade. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
dc.subject.other Citosina
dc.subject.other Càncer infantil
dc.subject.other Genòmica
dc.title 5-methylcytosine and 5-hydroxymethylcytosine signatures underlying pediatric cancers
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/epigenomes3020009
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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