5-methylcytosine and 5-hydroxymethylcytosine signatures underlying pediatric cancers
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- dc.contributor.author Jhanwar, Shalu, 1986-
- dc.contributor.author Deogade, Ajinkya, 1989-
- dc.date.accessioned 2022-04-27T10:58:07Z
- dc.date.available 2022-04-27T10:58:07Z
- dc.date.issued 2019
- dc.description.abstract In addition to the genetic variations, recent evidence has shown that DNA methylation of both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) underlies the pathogenesis of pediatric cancer. Given the high mortality rate, there is an urgent need to study the mechanisms contributing to the pathogenicity of pediatric cancer. Over the past decades, next-generation sequencing (NGS) has enabled us to perform genome-wide screening to study the complex regulatory mechanisms of 5mC and 5hmC underlying pediatric tumorigenesis. To shed light on recent developments on pediatric cancer predisposition and tumor progression, here we discuss the role of both genome-wide and locus-specific dysregulation of 5mC and 5hmC in hematopoiesis malignancy and neuroblastoma, the most common types of pediatric cancer, together with their therapeutic potential.
- dc.format.mimetype application/pdf
- dc.identifier.citation Jhanwar S, Deogade A. 5-methylcytosine and 5-hydroxymethylcytosine signatures underlying pediatric cancers. Epigenomes. 2019 May 9;3(2):9. DOI:10.3390/epigenomes3020009
- dc.identifier.doi http://dx.doi.org/10.3390/epigenomes3020009
- dc.identifier.issn 2075-4655
- dc.identifier.uri http://hdl.handle.net/10230/52915
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.uri http://creativecommons.org/licenses/by/4.0/
- dc.rights © 2019 by Shalu Jhanwar and Ajinkya Deogade. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Citosina
- dc.subject.other Càncer infantil
- dc.subject.other Genòmica
- dc.title 5-methylcytosine and 5-hydroxymethylcytosine signatures underlying pediatric cancers
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion