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Iodine deficiency and mortality in spanish adults: Di@bet.es study

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dc.contributor.author Maldonado-Araque, Cristina
dc.contributor.author Valdés, Sergio
dc.contributor.author Badía-Guillén, Rocío
dc.contributor.author Lago-Sampedro, Ana
dc.contributor.author Colomo, Natalia
dc.contributor.author García-Fuentes, Eduardo
dc.contributor.author Gutiérrez-Repiso, Carolina
dc.contributor.author Goday Arno, Alberto
dc.contributor.author Calle-Pascual, Alfonso
dc.contributor.author Castaño, Luis
dc.contributor.author Castell, Conxa
dc.contributor.author Delgado, Elías
dc.contributor.author Menéndez, Edelmiro
dc.contributor.author Franch-Nadal, Josep
dc.contributor.author Gaztambide, Sonia
dc.contributor.author Girbés, Juan
dc.contributor.author Chaves, Felipe Javier
dc.contributor.author Soriguer, Federico
dc.contributor.author Rojo-Martínez, Gemma
dc.date.accessioned 2022-02-21T08:02:23Z
dc.date.available 2022-02-21T08:02:23Z
dc.date.issued 2021
dc.identifier.citation Maldonado-Araque C, Valdés S, Badía-Guillén R, Lago-Sampedro A, Colomo N, Garcia-Fuentes E, et al. Iodine deficiency and mortality in spanish adults: Di@bet.es study. Thyroid. 2021 Jan; 31(1): 106-14. DOI: 10.1089/thy.2020.0131
dc.identifier.issn 1050-7256
dc.identifier.uri http://hdl.handle.net/10230/52531
dc.description.abstract Background: Longitudinal data assessing the impact of iodine deficiency (ID) on mortality are scarce. We aimed to study the association between the state of iodine nutrition and the risk of total and cause-specific mortality in a representative sample of the Spanish adult population. Methods: We performed a longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the nationwide study Di@bet.es (2008-2010). We used Cox regression to assess the association between UI at the start of the study (<50, 50-99, 100-199, 200-299, and ≥300 μg/L) and mortality during follow-up (National death registry-end of follow-up December 2016) in raw models, and adjusted for possible confounding variables: age, sex, educational level, hypertension, diabetes, obesity, chronic kidney disease, smoking, hypercholesterolemia, thyroid dysfunction, diagnosis of cardiovascular disease or cancer, area of residence, physical activity, adherence to Mediterranean diet, dairy and iodinated salt intake. Results: A total of 254 deaths were recorded during an average follow-up period of 7.3 years. The causes of death were cardiovascular 71 (28%); cancer 85 (33.5%); and other causes 98 (38.5%). Compared with the reference category with adequate iodine nutrition (UI 100-300 μg/L), the hazard ratios (HRs) of all-cause mortality in the category with UI ≥300 μg/L were 1.04 (95% confidence interval [CI 0.54-1.98]); however, in the categories with 50-99 UI and <50 μg/L, the HRs were 1.29 [CI 0.97-1.70] and 1.71 [1.18-2.48], respectively (p for trend 0.004). Multivariate adjustment did not significantly modify the results. Conclusions: Our data indicate an excess mortality in individuals with moderate-severe ID adjusted for other possible confounding factors.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Mary Ann Liebert, Inc
dc.rights This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Iodine deficiency and mortality in spanish adults: Di@bet.es study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1089/thy.2020.0131
dc.subject.keyword Spain
dc.subject.keyword Epidemiology
dc.subject.keyword Iodine
dc.subject.keyword Mortality
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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