Iodine deficiency and mortality in spanish adults: Di@bet.es study

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Maldonado-Araque, Cristina
  • dc.contributor.author Valdés, Sergio
  • dc.contributor.author Badía-Guillén, Rocío
  • dc.contributor.author Lago-Sampedro, Ana
  • dc.contributor.author Colomo, Natalia
  • dc.contributor.author García-Fuentes, Eduardo
  • dc.contributor.author Gutiérrez-Repiso, Carolina
  • dc.contributor.author Goday Arno, Alberto
  • dc.contributor.author Calle-Pascual, Alfonso
  • dc.contributor.author Castaño, Luis
  • dc.contributor.author Castell, Conxa
  • dc.contributor.author Delgado, Elías
  • dc.contributor.author Menéndez, Edelmiro
  • dc.contributor.author Franch-Nadal, Josep
  • dc.contributor.author Gaztambide, Sonia
  • dc.contributor.author Girbés, Juan
  • dc.contributor.author Chaves, Felipe Javier
  • dc.contributor.author Soriguer, Federico
  • dc.contributor.author Rojo-Martínez, Gemma
  • dc.date.accessioned 2022-02-21T08:02:23Z
  • dc.date.available 2022-02-21T08:02:23Z
  • dc.date.issued 2021
  • dc.description.abstract Background: Longitudinal data assessing the impact of iodine deficiency (ID) on mortality are scarce. We aimed to study the association between the state of iodine nutrition and the risk of total and cause-specific mortality in a representative sample of the Spanish adult population. Methods: We performed a longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the nationwide study Di@bet.es (2008-2010). We used Cox regression to assess the association between UI at the start of the study (<50, 50-99, 100-199, 200-299, and ≥300 μg/L) and mortality during follow-up (National death registry-end of follow-up December 2016) in raw models, and adjusted for possible confounding variables: age, sex, educational level, hypertension, diabetes, obesity, chronic kidney disease, smoking, hypercholesterolemia, thyroid dysfunction, diagnosis of cardiovascular disease or cancer, area of residence, physical activity, adherence to Mediterranean diet, dairy and iodinated salt intake. Results: A total of 254 deaths were recorded during an average follow-up period of 7.3 years. The causes of death were cardiovascular 71 (28%); cancer 85 (33.5%); and other causes 98 (38.5%). Compared with the reference category with adequate iodine nutrition (UI 100-300 μg/L), the hazard ratios (HRs) of all-cause mortality in the category with UI ≥300 μg/L were 1.04 (95% confidence interval [CI 0.54-1.98]); however, in the categories with 50-99 UI and <50 μg/L, the HRs were 1.29 [CI 0.97-1.70] and 1.71 [1.18-2.48], respectively (p for trend 0.004). Multivariate adjustment did not significantly modify the results. Conclusions: Our data indicate an excess mortality in individuals with moderate-severe ID adjusted for other possible confounding factors.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Maldonado-Araque C, Valdés S, Badía-Guillén R, Lago-Sampedro A, Colomo N, Garcia-Fuentes E, et al. Iodine deficiency and mortality in spanish adults: Di@bet.es study. Thyroid. 2021 Jan; 31(1): 106-14. DOI: 10.1089/thy.2020.0131
  • dc.identifier.doi http://dx.doi.org/10.1089/thy.2020.0131
  • dc.identifier.issn 1050-7256
  • dc.identifier.uri http://hdl.handle.net/10230/52531
  • dc.language.iso eng
  • dc.publisher Mary Ann Liebert, Inc
  • dc.rights This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.keyword Spain
  • dc.subject.keyword Epidemiology
  • dc.subject.keyword Iodine
  • dc.subject.keyword Mortality
  • dc.title Iodine deficiency and mortality in spanish adults: Di@bet.es study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

Col·leccions

Articles (Hospital del Mar Research Institute)