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Determinants of carbon load in airway macrophages in pregnant women

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dc.contributor.author Miri, Mohammad
dc.contributor.author Rezaei, Hossein
dc.contributor.author Momtaz, Seyed Mojtaba
dc.contributor.author Najafi, Moslem Lari
dc.contributor.author Adli, Abolfazl
dc.contributor.author Pajohanfar, Nasim Sadat
dc.contributor.author Abroudi, Mina
dc.contributor.author Bazghandi, Malihe Sadat
dc.contributor.author Razavi, Zahra
dc.contributor.author Alonso, Lucia
dc.contributor.author Tonne, Cathryn
dc.contributor.author Basagaña Flores, Xavier
dc.contributor.author Nieuwenhuijsen, Mark J.
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Nawrot, Tim S.
dc.contributor.author Dadvand, Payam
dc.date.accessioned 2022-02-18T06:47:30Z
dc.date.available 2022-02-18T06:47:30Z
dc.date.issued 2022
dc.identifier.citation Miri M, Rezaei H, Momtaz SM, Najafi ML, Adli A, Pajohanfar NS, Abroudi M, Bazghandi MS, Razavi Z, Alonso L, Tonne C, Basagaña X, Nieuwenhuijsen MJ, Sunyer J, Nawrot TS, Dadvand P. Determinants of carbon load in airway macrophages in pregnant women. Environ Pollut. 2022;297:118765. DOI: 10.1016/j.envpol.2021.118765
dc.identifier.issn 0269-7491
dc.identifier.uri http://hdl.handle.net/10230/52519
dc.description.abstract The airway macrophages carbon loading (AMCL) has been suggested to be a biomarker of the long-term exposure to air pollution; however, to date no study has characterized AMCL for the pregnancy period. Therefore, this study aimed to assess the determinants of AMCL during pregnancy in Iran, a middle-income country. This study was based on a sample of 234 pregnant women with term and normal vaginal delivery who were residing in Sabzevar, Iran (2019). We characterized 35 potential determinants of personal exposure to air pollution for each participant, including six personal, nine indoor, and 20 home-outdoor factors. We applied Deletion/Substitution/Addition algorithm to identify the most relevant determinants that could predict AMCL levels. The median (IQR) of AMCL level was 0.12 (0.30) μm2 with a successful sputum induction in 82.9% (194) of participants. Ambient residential PM2.5 levels were positively associated with higher AMCL levels. On the other hand, increased residential distance to the traffic lights, squares and ring-roads, the duration of opening window per day, and opening window during cooking were inversely associated with AMCL levels. Our findings provide novel insights on the different personal, indoor, and outdoor determinants of personal exposure to air pollution during pregnancy in a middle-income country.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Pollut. 2022;297:118765
dc.rights © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Determinants of carbon load in airway macrophages in pregnant women
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.envpol.2021.118765
dc.subject.keyword Air pollution
dc.subject.keyword Biomarker
dc.subject.keyword Lung
dc.subject.keyword Phagocytosis
dc.subject.keyword Pregnancy
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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