Determinants of carbon load in airway macrophages in pregnant women
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- dc.contributor.author Miri, Mohammad
- dc.contributor.author Rezaei, Hossein
- dc.contributor.author Momtaz, Seyed Mojtaba
- dc.contributor.author Najafi, Moslem Lari
- dc.contributor.author Adli, Abolfazl
- dc.contributor.author Pajohanfar, Nasim Sadat
- dc.contributor.author Abroudi, Mina
- dc.contributor.author Bazghandi, Malihe Sadat
- dc.contributor.author Razavi, Zahra
- dc.contributor.author Alonso, Lucia
- dc.contributor.author Tonne, Cathryn
- dc.contributor.author Basagaña Flores, Xavier
- dc.contributor.author Nieuwenhuijsen, Mark J.
- dc.contributor.author Sunyer Deu, Jordi
- dc.contributor.author Nawrot, Tim S.
- dc.contributor.author Dadvand, Payam
- dc.date.accessioned 2022-02-18T06:47:30Z
- dc.date.available 2022-02-18T06:47:30Z
- dc.date.issued 2022
- dc.description.abstract The airway macrophages carbon loading (AMCL) has been suggested to be a biomarker of the long-term exposure to air pollution; however, to date no study has characterized AMCL for the pregnancy period. Therefore, this study aimed to assess the determinants of AMCL during pregnancy in Iran, a middle-income country. This study was based on a sample of 234 pregnant women with term and normal vaginal delivery who were residing in Sabzevar, Iran (2019). We characterized 35 potential determinants of personal exposure to air pollution for each participant, including six personal, nine indoor, and 20 home-outdoor factors. We applied Deletion/Substitution/Addition algorithm to identify the most relevant determinants that could predict AMCL levels. The median (IQR) of AMCL level was 0.12 (0.30) μm2 with a successful sputum induction in 82.9% (194) of participants. Ambient residential PM2.5 levels were positively associated with higher AMCL levels. On the other hand, increased residential distance to the traffic lights, squares and ring-roads, the duration of opening window per day, and opening window during cooking were inversely associated with AMCL levels. Our findings provide novel insights on the different personal, indoor, and outdoor determinants of personal exposure to air pollution during pregnancy in a middle-income country.
- dc.format.mimetype application/pdf
- dc.identifier.citation Miri M, Rezaei H, Momtaz SM, Najafi ML, Adli A, Pajohanfar NS, Abroudi M, Bazghandi MS, Razavi Z, Alonso L, Tonne C, Basagaña X, Nieuwenhuijsen MJ, Sunyer J, Nawrot TS, Dadvand P. Determinants of carbon load in airway macrophages in pregnant women. Environ Pollut. 2022;297:118765. DOI: 10.1016/j.envpol.2021.118765
- dc.identifier.doi http://dx.doi.org/10.1016/j.envpol.2021.118765
- dc.identifier.issn 0269-7491
- dc.identifier.uri http://hdl.handle.net/10230/52519
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Environ Pollut. 2022;297:118765
- dc.rights © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Air pollution
- dc.subject.keyword Biomarker
- dc.subject.keyword Lung
- dc.subject.keyword Phagocytosis
- dc.subject.keyword Pregnancy
- dc.title Determinants of carbon load in airway macrophages in pregnant women
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion