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Environmental enrichment induces epigenomic and genome organization changes relevant for cognition

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dc.contributor.author Espeso Gil, Sergio, 1985-
dc.contributor.author Holik, Aliaksei Z.
dc.contributor.author Bonnin, Sarah
dc.contributor.author Jhanwar, Shalu, 1986-
dc.contributor.author Chandrasekaran, Sandhya
dc.contributor.author Pique Regi, Roger
dc.contributor.author Albaigès-Ràfols, Júlia
dc.contributor.author Maher, Michael
dc.contributor.author Permanyer, Jon
dc.contributor.author Irimia, Manuel
dc.contributor.author Friedländer, Marc R.
dc.contributor.author Pons Espinal, Meritxell, 1986-
dc.contributor.author Akbarian, Schahram
dc.contributor.author Dierssen, Mara
dc.contributor.author Maass, Philipp G.
dc.contributor.author Hor, Charlotte N.
dc.contributor.author Ossowski, Stephan
dc.date.accessioned 2021-11-25T06:51:38Z
dc.date.available 2021-11-25T06:51:38Z
dc.date.issued 2021
dc.identifier.citation Espeso-Gil S, Holik AZ, Bonnin S, Jhanwar S, Chandrasekaran S, Pique-Regi R, Albaigès-Ràfols J, Maher M, Permanyer J, Irimia M, Friedländer MR, Pons-Espinal M, Akbarian S, Dierssen M, Maass PG, Hor CN, Ossowski S. Environmental enrichment induces epigenomic and genome organization changes relevant for cognition. Front Mol Neurosci. 2021;14:664912. DOI: 10.3389/fnmol.2021.664912
dc.identifier.issn 1662-5099
dc.identifier.uri http://hdl.handle.net/10230/49052
dc.description.abstract In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organization, we used the paradigm of environmental enrichment (EE) in young mice constantly receiving novel stimulation. We profiled epigenome and chromatin architecture in whole cortex and sorted neurons by deep-sequencing techniques. Specifically, we studied chromatin accessibility, gene and protein regulation, and 3D genome conformation, combined with predicted enhancer and chromatin interactions. We identified increased chromatin accessibility, transcription factor binding including CTCF-mediated insulation, differential occupancy of H3K36me3 and H3K79me2, and changes in transcriptional programs required for neuronal development. EE stimuli led to local genome re-organization by inducing increased contacts between chromosomes 7 and 17 (inter-chromosomal). Our findings support the notion that EE-induced learning and memory processes are directly associated with the epigenome and genome organization.
dc.description.sponsorship We acknowledge support of the Spanish Ministry of Economy and Competitiveness (SAF2011-26216), “Centro de Excelencia Severo Ochoa 2017-2021,” SEV-2016-0571, the CERCA Programme/Generalitat de Catalunya and Jerome Lejeune Foundation, Swiss National Science Foundation Fellowship (PBLAP3_136878) and Co-funded by Marie Curie Actions to CNH. Resources for analyses conducted by SE-G were partially supported by the U.S. National Institutes of Mental Health Funds R01MH104341 and R01MH117790 and by the Social Sciences and Humanities Research Council of Canada (NFRFE-2018-01305). We acknowledge support of the Spanish Ministry of Science and Innovation to the EMBL partnership, Agencia Estatal de Investigaci n (PID2019-110755RB-I00/AEI / 10.13039/501100011033), the European Union’s Horizon 2020 Research and Innovation programme under grant agreement No 848077, Jerôme Lejeune Foundation, NIH (Grant Number: 1R01EB 028159-01), Marató TV3 (#2016/20-30). RP-R resources were supported by R01GM109215. We thank the support of the University of Tübingen for the Open Access Publication Funds contribution.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Front Mol Neurosci. 2021;14:664912
dc.rights © 2021 Espeso-Gil, Holik, Bonnin, Jhanwar, Chandrasekaran, Pique-Regi, Albaigès-Ràfols, Maher, Permanyer, Irimia, Friedländer, Pons-Espinal, Akbarian, Dierssen, Maass, Hor and Ossowski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Environmental enrichment induces epigenomic and genome organization changes relevant for cognition
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fnmol.2021.664912
dc.subject.keyword 3D genome organization
dc.subject.keyword Hi-C
dc.subject.keyword Chromatin accessibility
dc.subject.keyword Environmental enrichment
dc.subject.keyword Epigenetics
dc.subject.keyword Inter-chromosomal contacts
dc.subject.keyword Learning
dc.subject.keyword Postnatal development
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848077
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-26216
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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