Environmental enrichment induces epigenomic and genome organization changes relevant for cognition

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• dc.contributor.author Espeso Gil, Sergio, 1985-
• dc.contributor.author Holik, Aliaksei Z.
• dc.contributor.author Bonnin, Sarah
• dc.contributor.author Jhanwar, Shalu, 1986-
• dc.contributor.author Chandrasekaran, Sandhya
• dc.contributor.author Pique Regi, Roger
• dc.contributor.author Albaigès-Ràfols, Júlia
• dc.contributor.author Maher, Michael
• dc.contributor.author Permanyer, Jon
• dc.contributor.author Irimia Martínez, Manuel
• dc.contributor.author Friedländer, Marc R.
• dc.contributor.author Pons Espinal, Meritxell, 1986-
• dc.contributor.author Akbarian, Schahram
• dc.contributor.author Dierssen, Mara
• dc.contributor.author Maass, Philipp G.
• dc.contributor.author Hor, Charlotte N.
• dc.contributor.author Ossowski, Stephan
• dc.date.accessioned 2021-11-25T06:51:38Z
• dc.date.available 2021-11-25T06:51:38Z
• dc.date.issued 2021
• dc.description.abstract In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental stimulation impacts the epigenome and genome organization, we used the paradigm of environmental enrichment (EE) in young mice constantly receiving novel stimulation. We profiled epigenome and chromatin architecture in whole cortex and sorted neurons by deep-sequencing techniques. Specifically, we studied chromatin accessibility, gene and protein regulation, and 3D genome conformation, combined with predicted enhancer and chromatin interactions. We identified increased chromatin accessibility, transcription factor binding including CTCF-mediated insulation, differential occupancy of H3K36me3 and H3K79me2, and changes in transcriptional programs required for neuronal development. EE stimuli led to local genome re-organization by inducing increased contacts between chromosomes 7 and 17 (inter-chromosomal). Our findings support the notion that EE-induced learning and memory processes are directly associated with the epigenome and genome organization.
• dc.description.sponsorship We acknowledge support of the Spanish Ministry of Economy and Competitiveness (SAF2011-26216), “Centro de Excelencia Severo Ochoa 2017-2021,” SEV-2016-0571, the CERCA Programme/Generalitat de Catalunya and Jerome Lejeune Foundation, Swiss National Science Foundation Fellowship (PBLAP3_136878) and Co-funded by Marie Curie Actions to CNH. Resources for analyses conducted by SE-G were partially supported by the U.S. National Institutes of Mental Health Funds R01MH104341 and R01MH117790 and by the Social Sciences and Humanities Research Council of Canada (NFRFE-2018-01305). We acknowledge support of the Spanish Ministry of Science and Innovation to the EMBL partnership, Agencia Estatal de Investigaci n (PID2019-110755RB-I00/AEI / 10.13039/501100011033), the European Union’s Horizon 2020 Research and Innovation programme under grant agreement No 848077, Jerôme Lejeune Foundation, NIH (Grant Number: 1R01EB 028159-01), Marató TV3 (#2016/20-30). RP-R resources were supported by R01GM109215. We thank the support of the University of Tübingen for the Open Access Publication Funds contribution.
• dc.format.mimetype application/pdf
• dc.identifier.citation Espeso-Gil S, Holik AZ, Bonnin S, Jhanwar S, Chandrasekaran S, Pique-Regi R, Albaigès-Ràfols J, Maher M, Permanyer J, Irimia M, Friedländer MR, Pons-Espinal M, Akbarian S, Dierssen M, Maass PG, Hor CN, Ossowski S. Environmental enrichment induces epigenomic and genome organization changes relevant for cognition. Front Mol Neurosci. 2021;14:664912. DOI: 10.3389/fnmol.2021.664912
• dc.identifier.doi http://dx.doi.org/10.3389/fnmol.2021.664912
• dc.identifier.issn 1662-5099
• dc.identifier.uri http://hdl.handle.net/10230/49052
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Mol Neurosci. 2021;14:664912
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/848077
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-26216
• dc.rights © 2021 Espeso-Gil, Holik, Bonnin, Jhanwar, Chandrasekaran, Pique-Regi, Albaigès-Ràfols, Maher, Permanyer, Irimia, Friedländer, Pons-Espinal, Akbarian, Dierssen, Maass, Hor and Ossowski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword 3D genome organization
• dc.subject.keyword Hi-C
• dc.subject.keyword Chromatin accessibility
• dc.subject.keyword Environmental enrichment
• dc.subject.keyword Epigenetics
• dc.subject.keyword Inter-chromosomal contacts
• dc.subject.keyword Learning
• dc.subject.keyword Postnatal development
• dc.title Environmental enrichment induces epigenomic and genome organization changes relevant for cognition
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion