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A comprehensive map of predicted enhancers on a large panel of human primary cells, cell lines and tissues

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dc.contributor.author López Ruiz de Vargas, Sara
dc.date.accessioned 2021-11-18T10:52:26Z
dc.date.available 2021-11-18T10:52:26Z
dc.date.issued 2021
dc.identifier.uri http://hdl.handle.net/10230/49013
dc.description Treball de fi de grau en Bioinformàtica. Curs 2020-2021
dc.description Tutor: Trisevgeni Rapakoulia
dc.description.abstract We applied an enhancer prediction method to an extensive set of epigenetic profiles from the ENCODE project. We identified enhancer elements in 104 human primary cells, cell lines, and tissues. This extensive generation of enhancer profiles allowed us to identify groups of cell types that are pretty similar in terms of enhancer usage and cell types that differ significantly. A case study on adult brain and embryo placenta tissues with quite different sets of active enhancers revealed cell-type specific enhancers that regulate the expression of genes linked to the tissue phenotype. Further exploitation of additional cell groups can reveal the lineage-specific enhancers.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 license
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.other Treball de fi de grau – Curs 2020-2021
dc.subject.other Amplificació gènica
dc.subject.other Anàlisi de dades de panel
dc.title A comprehensive map of predicted enhancers on a large panel of human primary cells, cell lines and tissues
dc.type info:eu-repo/semantics/bachelorThesis
dc.subject.keyword Regulació de la transcripció
dc.subject.keyword Amplificadores
dc.subject.keyword Análisis de datos
dc.subject.keyword Regulación de la transcripción
dc.subject.keyword Enhancers
dc.subject.keyword Data analysis
dc.subject.keyword Transcription regulation
dc.rights.accessRights info:eu-repo/semantics/openAccess

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