A comprehensive map of predicted enhancers on a large panel of human primary cells, cell lines and tissues
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- dc.contributor.author López Ruiz de Vargas, Sara
- dc.date.accessioned 2021-11-18T10:52:26Z
- dc.date.available 2021-11-18T10:52:26Z
- dc.date.issued 2021
- dc.description Treball de fi de grau en Bioinformàtica. Curs 2020-2021ca
- dc.description Tutor: Trisevgeni Rapakouliaca
- dc.description.abstract We applied an enhancer prediction method to an extensive set of epigenetic profiles from the ENCODE project. We identified enhancer elements in 104 human primary cells, cell lines, and tissues. This extensive generation of enhancer profiles allowed us to identify groups of cell types that are pretty similar in terms of enhancer usage and cell types that differ significantly. A case study on adult brain and embryo placenta tissues with quite different sets of active enhancers revealed cell-type specific enhancers that regulate the expression of genes linked to the tissue phenotype. Further exploitation of additional cell groups can reveal the lineage-specific enhancers.en
- dc.format.mimetype application/pdf*
- dc.identifier.uri http://hdl.handle.net/10230/49013
- dc.language.iso engca
- dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 licenseca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/ca
- dc.subject.keyword Regulació de la transcripcióca
- dc.subject.keyword Amplificadores
- dc.subject.keyword Análisis de datos
- dc.subject.keyword Regulación de la transcripción
- dc.subject.keyword Enhancersen
- dc.subject.keyword Data analysisen
- dc.subject.keyword Transcription regulationen
- dc.subject.other Treball de fi de grau – Curs 2020-2021ca
- dc.subject.other Amplificació gènicaca
- dc.subject.other Anàlisi de dades de panelca
- dc.title A comprehensive map of predicted enhancers on a large panel of human primary cells, cell lines and tissuesca
- dc.type info:eu-repo/semantics/bachelorThesisca