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Beneficial effects of resveratrol in mouse gastrocnemius: a hint to muscle phenotype and proteolysis

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dc.contributor.author Mañas García, Laura, 1991-
dc.contributor.author Denhard, Charlotte
dc.contributor.author Mateu de Antonio, Francisco Javier
dc.contributor.author Duran Jordà, Xavier, 1974-
dc.contributor.author Gea Guiral, Joaquim
dc.contributor.author Barreiro Portela, Esther
dc.date.accessioned 2021-11-10T07:48:52Z
dc.date.available 2021-11-10T07:48:52Z
dc.date.issued 2021
dc.identifier.citation Mañas-García L, Denhard C, Mateu J, Duran X, Gea J, Barreiro E. Beneficial effects of resveratrol in mouse gastrocnemius: a hint to muscle phenotype and proteolysis. Cells. 2021;10(9):2436. DOI: 10.3390/cells10092436
dc.identifier.issn 2073-4409
dc.identifier.uri http://hdl.handle.net/10230/48939
dc.description.abstract We hypothesized that the phenolic compound resveratrol mitigates muscle protein degradation and loss and improves muscle fiber cross-sectional area (CSA) in gastrocnemius of mice exposed to unloading (7dI). In gastrocnemius of mice (female C57BL/6J, 10 weeks) exposed to a seven-day period of hindlimb immobilization with/without resveratrol treatment, markers of muscle proteolysis (tyrosine release, systemic troponin-I), atrophy signaling pathways, and muscle phenotypic features and function were analyzed. In gastrocnemius of unloaded mice treated with resveratrol, body and muscle weight and function were attenuated, whereas muscle proteolysis (tyrosine release), proteolytic and apoptotic markers, atrophy signaling pathways, and myofiber CSA significantly improved. Resveratrol treatment of mice exposed to a seven-day period of unloading prevented body and muscle weight and limb strength loss, while an improvement in muscle proteolysis, proteolytic markers, atrophy signaling pathways, apoptosis, and muscle fiber CSA was observed in the gastrocnemius muscle. These findings may have potential therapeutic implications in the management of disuse muscle atrophy in clinical settings.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Cells. 2021;10(9):2436
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Beneficial effects of resveratrol in mouse gastrocnemius: a hint to muscle phenotype and proteolysis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/cells10092436
dc.subject.keyword Apoptosis
dc.subject.keyword Atrophy signaling pathways
dc.subject.keyword Chronic conditions
dc.subject.keyword Disuse muscle atrophy
dc.subject.keyword Limb muscles
dc.subject.keyword Muscle fiber cross-sectional areas
dc.subject.keyword Proteolysis
dc.subject.keyword Resveratrol
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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