Beneficial effects of resveratrol in mouse gastrocnemius: a hint to muscle phenotype and proteolysis

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• dc.contributor.author Mañas García, Laura, 1991-
• dc.contributor.author Denhard, Charlotte
• dc.contributor.author Mateu de Antonio, Francisco Javier
• dc.contributor.author Duran Jordà, Xavier, 1974-
• dc.contributor.author Gea Guiral, Joaquim
• dc.contributor.author Barreiro Portela, Esther
• dc.date.accessioned 2021-11-10T07:48:52Z
• dc.date.available 2021-11-10T07:48:52Z
• dc.date.issued 2021
• dc.description.abstract We hypothesized that the phenolic compound resveratrol mitigates muscle protein degradation and loss and improves muscle fiber cross-sectional area (CSA) in gastrocnemius of mice exposed to unloading (7dI). In gastrocnemius of mice (female C57BL/6J, 10 weeks) exposed to a seven-day period of hindlimb immobilization with/without resveratrol treatment, markers of muscle proteolysis (tyrosine release, systemic troponin-I), atrophy signaling pathways, and muscle phenotypic features and function were analyzed. In gastrocnemius of unloaded mice treated with resveratrol, body and muscle weight and function were attenuated, whereas muscle proteolysis (tyrosine release), proteolytic and apoptotic markers, atrophy signaling pathways, and myofiber CSA significantly improved. Resveratrol treatment of mice exposed to a seven-day period of unloading prevented body and muscle weight and limb strength loss, while an improvement in muscle proteolysis, proteolytic markers, atrophy signaling pathways, apoptosis, and muscle fiber CSA was observed in the gastrocnemius muscle. These findings may have potential therapeutic implications in the management of disuse muscle atrophy in clinical settings.
• dc.format.mimetype application/pdf
• dc.identifier.citation Mañas-García L, Denhard C, Mateu J, Duran X, Gea J, Barreiro E. Beneficial effects of resveratrol in mouse gastrocnemius: a hint to muscle phenotype and proteolysis. Cells. 2021;10(9):2436. DOI: 10.3390/cells10092436
• dc.identifier.doi http://dx.doi.org/10.3390/cells10092436
• dc.identifier.issn 2073-4409
• dc.identifier.uri http://hdl.handle.net/10230/48939
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Cells. 2021;10(9):2436
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Apoptosis
• dc.subject.keyword Atrophy signaling pathways
• dc.subject.keyword Chronic conditions
• dc.subject.keyword Disuse muscle atrophy
• dc.subject.keyword Limb muscles
• dc.subject.keyword Muscle fiber cross-sectional areas
• dc.subject.keyword Proteolysis
• dc.subject.keyword Resveratrol
• dc.title Beneficial effects of resveratrol in mouse gastrocnemius: a hint to muscle phenotype and proteolysis
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion