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Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation

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dc.contributor.author Arenas, M. Carmen
dc.contributor.author Castro Zavala, Adriana, 1988-
dc.contributor.author Martín Sánchez, Ana
dc.contributor.author Blanco-Gandía, M. Carmen
dc.contributor.author Miñarro, José
dc.contributor.author Valverde Granados, Olga
dc.contributor.author Manzanedo, Carmen
dc.date.accessioned 2021-10-19T06:09:52Z
dc.date.available 2021-10-19T06:09:52Z
dc.date.issued 2022
dc.identifier.citation Arenas MC, Castro-Zavala A, Martín-Sánchez A, Blanco-Gandía MC, Miñarro J, Valverde O, Manzanedo C. Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation. Behav Brain Res. 2022;416:113545. DOI: 10.1016/j.bbr.2021.113545
dc.identifier.issn 0166-4328
dc.identifier.uri http://hdl.handle.net/10230/48692
dc.description.abstract The prepulse inhibition (PPI) of the startle response can identify the rodents that are more sensitive to the effects of cocaine. Mice with a lower PPI presented a higher vulnerability to the effects of cocaine and a higher susceptibility to developing a substance use disorder (SUD). Maternal separation with early weaning (MSEW) is a relevant animal model to induce motivational alterations throughout life. Nevertheless, only a few studies on females exist, even though they are more vulnerable to stress- and cocaine-related problems. Hence, the aim of the present study was to evaluate the ability of PPI to identify females with a greater vulnerability to the long-term consequences of early stress on the motivational effects of cocaine. Female mice underwent MSEW and were classified according to their high or low PPI. They were then assessed in the cocaine-induced locomotor sensitization test, the conditioned place preference paradigm or the operant self-administration paradigm. Additionally, they were also evaluated in the passive avoidance task, the tail-suspension and the splash tests. The results revealed that the females with lower PPI presented higher consequences of MSEW on the effects of cocaine and showed an increase in anhedonia-like behaviours. Our findings support that a PPI deficit could represent a biomarker of vulnerability to the effects of cocaine induced by MSEW.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Behav Brain Res. 2022;416:113545
dc.rights © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.bbr.2021.113545
dc.subject.keyword Anhedonia-like behaviours
dc.subject.keyword Cocaine
dc.subject.keyword Female mice
dc.subject.keyword Maternal separation with early weaning
dc.subject.keyword Prepulse inhibition
dc.subject.keyword Reinforcing effects
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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