Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation

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• dc.contributor.author Arenas, M. Carmen
• dc.contributor.author Castro Zavala, Adriana, 1988-
• dc.contributor.author Martín Sánchez, Ana
• dc.contributor.author Blanco-Gandía, M. Carmen
• dc.contributor.author Miñarro, José
• dc.contributor.author Valverde Granados, Olga
• dc.contributor.author Manzanedo, Carmen
• dc.date.accessioned 2021-10-19T06:09:52Z
• dc.date.available 2021-10-19T06:09:52Z
• dc.date.issued 2022
• dc.description.abstract The prepulse inhibition (PPI) of the startle response can identify the rodents that are more sensitive to the effects of cocaine. Mice with a lower PPI presented a higher vulnerability to the effects of cocaine and a higher susceptibility to developing a substance use disorder (SUD). Maternal separation with early weaning (MSEW) is a relevant animal model to induce motivational alterations throughout life. Nevertheless, only a few studies on females exist, even though they are more vulnerable to stress- and cocaine-related problems. Hence, the aim of the present study was to evaluate the ability of PPI to identify females with a greater vulnerability to the long-term consequences of early stress on the motivational effects of cocaine. Female mice underwent MSEW and were classified according to their high or low PPI. They were then assessed in the cocaine-induced locomotor sensitization test, the conditioned place preference paradigm or the operant self-administration paradigm. Additionally, they were also evaluated in the passive avoidance task, the tail-suspension and the splash tests. The results revealed that the females with lower PPI presented higher consequences of MSEW on the effects of cocaine and showed an increase in anhedonia-like behaviours. Our findings support that a PPI deficit could represent a biomarker of vulnerability to the effects of cocaine induced by MSEW.
• dc.format.mimetype application/pdf
• dc.identifier.citation Arenas MC, Castro-Zavala A, Martín-Sánchez A, Blanco-Gandía MC, Miñarro J, Valverde O, Manzanedo C. Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation. Behav Brain Res. 2022;416:113545. DOI: 10.1016/j.bbr.2021.113545
• dc.identifier.doi http://dx.doi.org/10.1016/j.bbr.2021.113545
• dc.identifier.issn 0166-4328
• dc.identifier.uri http://hdl.handle.net/10230/48692
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Behav Brain Res. 2022;416:113545
• dc.rights © 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Anhedonia-like behaviours
• dc.subject.keyword Cocaine
• dc.subject.keyword Female mice
• dc.subject.keyword Maternal separation with early weaning
• dc.subject.keyword Prepulse inhibition
• dc.subject.keyword Reinforcing effects
• dc.title Prepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion