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A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome

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dc.contributor.author Khannous Lleiffe, Olfat
dc.contributor.author Willis, Jesse R.
dc.contributor.author Saus Martínez, Ester
dc.contributor.author Cabrera-Aguilera, Ignacio
dc.contributor.author Almendros, Isaac
dc.contributor.author Farré, Ramon
dc.contributor.author Gozal, David
dc.contributor.author Farré López, Núria
dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.date.accessioned 2021-10-04T06:41:22Z
dc.date.available 2021-10-04T06:41:22Z
dc.date.issued 2021
dc.identifier.citation Khannous-Lleiffe O, Willis JR, Saus E, Cabrera-Aguilera I, Almendros I, Farré R, Gozal D, Farré N, Gabaldón T. A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome. Microorganisms. 2021;9(3):641. DOI: 10.3390/microorganisms9030641
dc.identifier.issn 2076-2607
dc.identifier.uri http://hdl.handle.net/10230/48554
dc.description.abstract Heart failure (HF) is a common condition associated with a high rate of hospitalizations and adverse outcomes. HF is characterized by impairments of either the cardiac ventricular filling, ejection of blood capacity or both. Sleep fragmentation (SF) involves a series of short sleep interruptions that lead to fatigue and contribute to cognitive impairments and dementia. Both conditions are known to be associated with increased inflammation and dysbiosis of the gut microbiota. In the present study, mice were distributed into four groups, and subjected for four weeks to either HF, SF, both HF and SF, or left unperturbed as controls. We used 16S metabarcoding to assess fecal microbiome composition before and after the experiments. Evidence for distinct alterations in several bacterial groups and an overall decrease in alpha diversity emerged in HF and SF treatment groups. Combined HF and SF conditions, however, showed no synergism, and observed changes were not always additive, suggesting preliminarily that some of the individual effects of either HF or SF cancel each other out when applied concomitantly.
dc.description.sponsorship I.C.-A. was supported by CONICYT PFCHA—Chilean Doctorate Fellowship 2017; Grant No. 72180089. R.F. was supported in part by the Spanish Ministry of Economy and Competitiveness (SAF2017-85574-R). D.G. was supported in part by National Institutes of Health grants HL130984 and HL140548. T.G. group acknowledges support from the Spanish Ministry of Science and Innovation for grant PGC2018-099921-B-I00, cofounded by European Regional Development Fund (ERDF); from the CERCA Programme/Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR423. from the European Union’s Horizon 2020 research and innovation programme under the grant agreement ERC-2016-724173; and from Instituto de Salud Carlos III (INB Grant, PT17/0009/0023-ISCIII-SGEFI/ERDF).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartof Microorganisms. 2021;9(3):641
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/microorganisms9030641
dc.subject.keyword Heart failure
dc.subject.keyword Metagenomics
dc.subject.keyword Microbiome
dc.subject.keyword Sleep apnea
dc.subject.keyword Sleep fragmentation
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724173
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-85574-R
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-099921-B-I00
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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