A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome

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  • dc.contributor.author Khannous Lleiffe, Olfat
  • dc.contributor.author Willis, Jesse R.
  • dc.contributor.author Saus Martínez, Ester
  • dc.contributor.author Cabrera-Aguilera, Ignacio
  • dc.contributor.author Almendros, Isaac
  • dc.contributor.author Farré, Ramon
  • dc.contributor.author Gozal, David
  • dc.contributor.author Farré López, Núria
  • dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
  • dc.date.accessioned 2021-10-04T06:41:22Z
  • dc.date.available 2021-10-04T06:41:22Z
  • dc.date.issued 2021
  • dc.description.abstract Heart failure (HF) is a common condition associated with a high rate of hospitalizations and adverse outcomes. HF is characterized by impairments of either the cardiac ventricular filling, ejection of blood capacity or both. Sleep fragmentation (SF) involves a series of short sleep interruptions that lead to fatigue and contribute to cognitive impairments and dementia. Both conditions are known to be associated with increased inflammation and dysbiosis of the gut microbiota. In the present study, mice were distributed into four groups, and subjected for four weeks to either HF, SF, both HF and SF, or left unperturbed as controls. We used 16S metabarcoding to assess fecal microbiome composition before and after the experiments. Evidence for distinct alterations in several bacterial groups and an overall decrease in alpha diversity emerged in HF and SF treatment groups. Combined HF and SF conditions, however, showed no synergism, and observed changes were not always additive, suggesting preliminarily that some of the individual effects of either HF or SF cancel each other out when applied concomitantly.
  • dc.description.sponsorship I.C.-A. was supported by CONICYT PFCHA—Chilean Doctorate Fellowship 2017; Grant No. 72180089. R.F. was supported in part by the Spanish Ministry of Economy and Competitiveness (SAF2017-85574-R). D.G. was supported in part by National Institutes of Health grants HL130984 and HL140548. T.G. group acknowledges support from the Spanish Ministry of Science and Innovation for grant PGC2018-099921-B-I00, cofounded by European Regional Development Fund (ERDF); from the CERCA Programme/Generalitat de Catalunya; from the Catalan Research Agency (AGAUR) SGR423. from the European Union’s Horizon 2020 research and innovation programme under the grant agreement ERC-2016-724173; and from Instituto de Salud Carlos III (INB Grant, PT17/0009/0023-ISCIII-SGEFI/ERDF).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Khannous-Lleiffe O, Willis JR, Saus E, Cabrera-Aguilera I, Almendros I, Farré R, Gozal D, Farré N, Gabaldón T. A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome. Microorganisms. 2021;9(3):641. DOI: 10.3390/microorganisms9030641
  • dc.identifier.doi http://dx.doi.org/10.3390/microorganisms9030641
  • dc.identifier.issn 2076-2607
  • dc.identifier.uri http://hdl.handle.net/10230/48554
  • dc.language.iso eng
  • dc.publisher MDPI
  • dc.relation.ispartof Microorganisms. 2021;9(3):641
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/724173
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-85574-R
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-099921-B-I00
  • dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Heart failure
  • dc.subject.keyword Metagenomics
  • dc.subject.keyword Microbiome
  • dc.subject.keyword Sleep apnea
  • dc.subject.keyword Sleep fragmentation
  • dc.title A mouse model suggests that heart failure and its common comorbidity sleep fragmentation have no synergistic impacts on the gut microbiome
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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