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dc.contributor.author | Hernáez, Álvaro |
dc.contributor.author | Soria-Florido, Maria |
dc.contributor.author | Castañer, Olga |
dc.contributor.author | Pintó Sala, Xavier |
dc.contributor.author | Estruch, Ramón |
dc.contributor.author | Salas Salvadó, Jordi |
dc.contributor.author | Corella, Dolores |
dc.contributor.author | Alonso-Gómez, Ángel |
dc.contributor.author | Martínez-González, Miguel A. |
dc.contributor.author | Schröder, Helmut, 1958- |
dc.contributor.author | Ros, Emilio |
dc.contributor.author | Serra Majem, Lluís |
dc.contributor.author | Fiol, Miquel |
dc.contributor.author | Lapetra, José |
dc.contributor.author | Gómez Gracia, Enrique |
dc.contributor.author | Fitó Colomer, Montserrat |
dc.contributor.author | Lassale, Camille |
dc.date.accessioned | 2021-09-15T06:39:45Z |
dc.date.available | 2021-09-15T06:39:45Z |
dc.date.issued | 2021 |
dc.identifier.citation | Hernáez Á, Soria-Florido MT, Castañer O, Pintó X, Estruch R, Salas-Salvadó J, Corella D, Alonso-Gómez Á, Martínez-González MÁ, Schröder H, Ros E, Serra-Majem L, Fiol M, Lapetra J, Gomez-Gracia E, Fitó M, Lassale C. Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study. Eur J Prev Cardiol. 2021;28(12):1392-401. DOI: 10.1177/2047487320925625 |
dc.identifier.issn | 2047-4873 |
dc.identifier.uri | http://hdl.handle.net/10230/48456 |
dc.description.abstract | Aims: Physical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits. Methods: The study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariable linear regression models were used to explore the association between leisure time physical activity (exposure) and each high-density lipoprotein functional trait (outcome), adjusted for cardiovascular risk factors. Results: Higher levels of leisure time physical activity were positively and linearly associated with average levels over one year of plasma high-density lipoprotein-cholesterol and apolipoprotein A-I, paraoxonase-1 antioxidant activity, high-density lipoprotein capacity to esterify cholesterol and cholesterol efflux capacity in individuals free of type 2 diabetes only. The increased cholesterol esterification index with increasing leisure time physical activity reached a plateau at around 300 metabolic equivalents.min/day. In individuals with diabetes, the relationship with cholesteryl ester transfer protein followed a U-shape, with a decreased cholesteryl ester transfer protein activity from 0 to 300 metabolic equivalents.min/day, but increasing from there onwards. Increasing levels of leisure time physical activity were associated with poorer high-density lipoprotein vasodilatory capacity. Conclusions: In a high cardiovascular risk population, leisure time physical activity was associated not only with greater circulating levels of high-density lipoprotein-cholesterol, but also with better markers of high-density lipoprotein functionality, namely cholesterol efflux capacity, the capacity of high-density lipoprotein to esterify cholesterol and paraoxonase-1 antioxidant activity in individuals free of diabetes and lower cholesteryl ester transfer protein activity in individuals with type 2 diabetes. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Oxford University Press |
dc.relation.ispartof | Eur J Prev Cardiol. 2021;28(12):1392-401 |
dc.rights | © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in European journal of preventive cardiology following peer review. The version of record Hernáez Á, Soria-Florido MT, Castañer O, Pintó X, Estruch R, Salas-Salvadó J, Corella D, Alonso-Gómez Á, Martínez-González MÁ, Schröder H, Ros E, Serra-Majem L, Fiol M, Lapetra J, Gomez-Gracia E, Fitó M, Lassale C. Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study. Eur J Prev Cardiol. 2021;28(12):1392-401. DOI: 10.1177/2047487320925625 is available online at: http://dx.doi.org/10.1177/2047487320925625. |
dc.title | Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1177/2047487320925625 |
dc.subject.keyword | HDL function |
dc.subject.keyword | Biomarkers |
dc.subject.keyword | Lifestyle |
dc.subject.keyword | Physical activity |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/acceptedVersion |