Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study

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• dc.contributor.author Hernáez, Álvaro
• dc.contributor.author Soria-Florido, Maria
• dc.contributor.author Castañer, Olga
• dc.contributor.author Pintó Sala, Xavier
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Corella, Dolores
• dc.contributor.author Alonso-Gómez, Ángel
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Schröder, Helmut, 1958-
• dc.contributor.author Ros, Emilio
• dc.contributor.author Serra Majem, Lluís
• dc.contributor.author Fiol, Miquel
• dc.contributor.author Lapetra, José
• dc.contributor.author Gómez Gracia, Enrique
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Lassale, Camille
• dc.date.accessioned 2021-09-15T06:39:45Z
• dc.date.available 2021-09-15T06:39:45Z
• dc.date.issued 2021
• dc.description.abstract Aims: Physical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits. Methods: The study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariable linear regression models were used to explore the association between leisure time physical activity (exposure) and each high-density lipoprotein functional trait (outcome), adjusted for cardiovascular risk factors. Results: Higher levels of leisure time physical activity were positively and linearly associated with average levels over one year of plasma high-density lipoprotein-cholesterol and apolipoprotein A-I, paraoxonase-1 antioxidant activity, high-density lipoprotein capacity to esterify cholesterol and cholesterol efflux capacity in individuals free of type 2 diabetes only. The increased cholesterol esterification index with increasing leisure time physical activity reached a plateau at around 300 metabolic equivalents.min/day. In individuals with diabetes, the relationship with cholesteryl ester transfer protein followed a U-shape, with a decreased cholesteryl ester transfer protein activity from 0 to 300 metabolic equivalents.min/day, but increasing from there onwards. Increasing levels of leisure time physical activity were associated with poorer high-density lipoprotein vasodilatory capacity. Conclusions: In a high cardiovascular risk population, leisure time physical activity was associated not only with greater circulating levels of high-density lipoprotein-cholesterol, but also with better markers of high-density lipoprotein functionality, namely cholesterol efflux capacity, the capacity of high-density lipoprotein to esterify cholesterol and paraoxonase-1 antioxidant activity in individuals free of diabetes and lower cholesteryl ester transfer protein activity in individuals with type 2 diabetes.
• dc.format.mimetype application/pdf
• dc.identifier.citation Hernáez Á, Soria-Florido MT, Castañer O, Pintó X, Estruch R, Salas-Salvadó J, Corella D, Alonso-Gómez Á, Martínez-González MÁ, Schröder H, Ros E, Serra-Majem L, Fiol M, Lapetra J, Gomez-Gracia E, Fitó M, Lassale C. Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study. Eur J Prev Cardiol. 2021;28(12):1392-401. DOI: 10.1177/2047487320925625
• dc.identifier.doi http://dx.doi.org/10.1177/2047487320925625
• dc.identifier.issn 2047-4873
• dc.identifier.uri http://hdl.handle.net/10230/48456
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Eur J Prev Cardiol. 2021;28(12):1392-401
• dc.rights © Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in European journal of preventive cardiology following peer review. The version of record Hernáez Á, Soria-Florido MT, Castañer O, Pintó X, Estruch R, Salas-Salvadó J, Corella D, Alonso-Gómez Á, Martínez-González MÁ, Schröder H, Ros E, Serra-Majem L, Fiol M, Lapetra J, Gomez-Gracia E, Fitó M, Lassale C. Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study. Eur J Prev Cardiol. 2021;28(12):1392-401. DOI: 10.1177/2047487320925625 is available online at: http://dx.doi.org/10.1177/2047487320925625.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword HDL function
• dc.subject.keyword Biomarkers
• dc.subject.keyword Lifestyle
• dc.subject.keyword Physical activity
• dc.title Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion