dc.contributor.author |
Ramos Campoy, Silvia |
dc.contributor.author |
Puiggros Metje, Anna Maria |
dc.contributor.author |
Gimeno Vázquez, Eva |
dc.contributor.author |
Espinet Solà, Blanca |
dc.date.accessioned |
2021-06-17T06:17:48Z |
dc.date.available |
2021-06-17T06:17:48Z |
dc.date.issued |
2022 |
dc.identifier.citation |
Ramos-Campoy S, Puiggros A, Beà S, Bougeon S, Larráyoz MJ, Costa D et al. Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients. Haematologica. 2022;107(3):593-603. DOI: 10.3324/haematol.2020.274456 |
dc.identifier.issn |
0390-6078 |
dc.identifier.uri |
http://hdl.handle.net/10230/47912 |
dc.description.abstract |
Genome complexity has been associated with poor outcome in patients with chronic lymphocytic leukemia (CLL). Previous cooperative studies established five abnormalities as the cut-off that best predicts an adverse evolution by chromosome banding analysis (CBA) and genomic microarrays (GM). However, data comparing risk stratification by both methods are scarce. Herein, we assessed a cohort of 340 untreated CLL patients highly enriched in cases with complex karyotype (CK, 46.5%) with parallel CBA and GM studies. Abnormalities found by both techniques were compared. Prognostic stratification in three risk groups based on genomic complexity [0-2, 3-4 and ≥5 abnormalities] was also analyzed. No significant differences in the percentage of patients classified into each category were detected, but only a moderate agreement was observed between methods when focusing in individual cases (κ=0.507; p. |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Ferrata Storti Foundation |
dc.relation.ispartof |
Haematologica. 2022;107(3):593-603 |
dc.rights |
© 2021 Ferrata Storti Foundation. Papers in Haematologica are published under a Creative Commons license CC BY-NC-ND. According to this license, an article may be copied, displayed, distributed, republished or otherwise reused provided the reuse is not an adaptation or a modification and the integrity of the original paper is maintained. This license does not allow for any kind of commercial use of the paper. For more details, see About Haematologica. |
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0 |
dc.title |
Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.3324/haematol.2020.274456 |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/publishedVersion |