Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients

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• dc.contributor.author Ramos Campoy, Silvia
• dc.contributor.author Puiggros Metje, Anna Maria
• dc.contributor.author Gimeno Vázquez, Eva
• dc.contributor.author Espinet Solà, Blanca
• dc.date.accessioned 2021-06-17T06:17:48Z
• dc.date.available 2021-06-17T06:17:48Z
• dc.date.issued 2022
• dc.description.abstract Genome complexity has been associated with poor outcome in patients with chronic lymphocytic leukemia (CLL). Previous cooperative studies established five abnormalities as the cut-off that best predicts an adverse evolution by chromosome banding analysis (CBA) and genomic microarrays (GM). However, data comparing risk stratification by both methods are scarce. Herein, we assessed a cohort of 340 untreated CLL patients highly enriched in cases with complex karyotype (CK, 46.5%) with parallel CBA and GM studies. Abnormalities found by both techniques were compared. Prognostic stratification in three risk groups based on genomic complexity [0-2, 3-4 and ≥5 abnormalities] was also analyzed. No significant differences in the percentage of patients classified into each category were detected, but only a moderate agreement was observed between methods when focusing in individual cases (κ=0.507; p.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ramos-Campoy S, Puiggros A, Beà S, Bougeon S, Larráyoz MJ, Costa D et al. Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients. Haematologica. 2022;107(3):593-603. DOI: 10.3324/haematol.2020.274456
• dc.identifier.doi http://dx.doi.org/10.3324/haematol.2020.274456
• dc.identifier.issn 0390-6078
• dc.identifier.uri http://hdl.handle.net/10230/47912
• dc.language.iso eng
• dc.publisher Ferrata Storti Foundation
• dc.relation.ispartof Haematologica. 2022;107(3):593-603
• dc.rights © 2021 Ferrata Storti Foundation. Papers in Haematologica are published under a Creative Commons license CC BY-NC-ND. According to this license, an article may be copied, displayed, distributed, republished or otherwise reused provided the reuse is not an adaptation or a modification and the integrity of the original paper is maintained. This license does not allow for any kind of commercial use of the paper. For more details, see About Haematologica.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0
• dc.title Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion