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Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4

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dc.contributor.author Sánchez Benavides, Gonzalo
dc.contributor.author Salvadó, Gemma
dc.contributor.author Arenaza Urquijo, Eider M.
dc.contributor.author Grau-Rivera, Oriol
dc.contributor.author Suárez-Calvet, Marc
dc.contributor.author Milà Alomà, Marta
dc.contributor.author González de Echávarri, José Maria
dc.contributor.author Minguillón, Carolina
dc.contributor.author Crous-Bou, Marta
dc.contributor.author Niñerola-Baizán, Aida
dc.contributor.author Perissinotti, Andrés
dc.contributor.author Gispert López, Juan Domingo
dc.contributor.author Molinuevo, José Luis
dc.contributor.author ALFA Study
dc.date.accessioned 2021-05-18T07:00:17Z
dc.date.available 2021-05-18T07:00:17Z
dc.date.issued 2020
dc.identifier.citation Sánchez-Benavides G, Salvadó G, Arenaza-Urquijo EM, Grau-Rivera O, Suárez-Calvet M, Milà-Alomà M, et al. Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4. Alzheimers Dement (Amst). 2020 Nov 11; 12(1): e12127. DOI: 10.1002/dad2.12127
dc.identifier.issn 2352-8729
dc.identifier.uri http://hdl.handle.net/10230/47574
dc.description.abstract Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals. Methods: A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status. Results: Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003). Discussion: Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.
dc.description.sponsorship The project leading to these results has received funding from “la Caixa” Foundation (ID 100010434), under agreement LCF/PR/GN17/50300004 and the Alzheimer's Association and an international anonymous charity foundation through the TriBEKa Imaging Platform project (TriBEKa‐17‐519007). Additional support has been received from the Universities and Research Secretariat, Ministry of Business and Knowledge of the Catalan Government under the grant no. 2017‐SGR‐892. Marc Suárez‐Calvet received funding from the European Union's Horizon 2020 Research and Innovation Program under the Marie Sklodowska‐Curie action grant agreement No 752310, and currently receives funding from Instituto de Salud Carlos III (PI19/00155) and from the Spanish Ministry of Science, Innovation, and Universities (Juan de la Cierva Programme grant IJC2018‐037478‐I). Juan Domingo Gispert is supported by the Spanish Ministry of Science and Innovation (RYC‐2013‐13054). Oriol Grau‐Rivera is supported by the Spanish Ministry of Science, Innovation, and Universities (FJCI‐2017‐33437). ASV is the recipient of an Instituto de Salud Carlos III Miguel Servet II fellowship (CP II 17/00029). Eider M. Arenaza‐Urquijo is supported by the Spanish Ministry of Science, Innovation and Universities–Spanish State Research Agency (RYC2018‐026053‐I). Carolina Minguillon was supported by the Spanish Ministry of Economy and Competitiveness (grant n° IEDI‐2016‐00690).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights Copyright © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.title Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/dad2.12127
dc.subject.keyword Alzheimer's disease
dc.subject.keyword Amyloid
dc.subject.keyword Informant reports
dc.subject.keyword Preclinical
dc.subject.keyword Subjective cognitive decline
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/752310
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/RYC2013‐13054
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/FJCI2017‐33437
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RYC2018‐026053‐I
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/IEDI‐2016‐00690
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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