Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4

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  • dc.contributor.author Sánchez Benavides, Gonzalo
  • dc.contributor.author Salvadó, Gemma
  • dc.contributor.author Arenaza Urquijo, Eider M.
  • dc.contributor.author Grau-Rivera, Oriol
  • dc.contributor.author Suárez-Calvet, Marc
  • dc.contributor.author Milà Alomà, Marta
  • dc.contributor.author González de Echávarri, José Maria
  • dc.contributor.author Minguillón, Carolina
  • dc.contributor.author Crous-Bou, Marta
  • dc.contributor.author Niñerola-Baizán, Aida
  • dc.contributor.author Perissinotti, Andrés
  • dc.contributor.author Gispert López, Juan Domingo
  • dc.contributor.author Molinuevo, José Luis
  • dc.contributor.author ALFA Study
  • dc.date.accessioned 2021-05-18T07:00:17Z
  • dc.date.available 2021-05-18T07:00:17Z
  • dc.date.issued 2020
  • dc.description.abstract Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) outcome in cognitively unimpaired middle-aged individuals. Methods: A total of 261 participants from the ALFA+ study underwent [18F]flutemetamol PET and Subjective Cognitive Decline Questionnaire (SCD-Q) concurrently, and 3 years before scan. We used logistic regressions to evaluate the ability of SCD-Q scores (self and informant) to predict Aβ PET visual read, and repeated analysis of variance to assess whether changes in SCD-Q scores relate to Aβ status. Results: Self-perception of decline in memory (odds ratio [OR] = 1.2), and informant perception of executive decline (OR = 1.6), increased the probability of a positive scan. Informant reports 3 years before scanning predicted Aβ PET outcome. Longitudinal increase of self-reported executive decline was predictive of Aβ in women (P = .003). Discussion: Subjective reports of cognitive decline are useful to predict Aβ and may improve recruitment strategies.
  • dc.description.sponsorship The project leading to these results has received funding from “la Caixa” Foundation (ID 100010434), under agreement LCF/PR/GN17/50300004 and the Alzheimer's Association and an international anonymous charity foundation through the TriBEKa Imaging Platform project (TriBEKa‐17‐519007). Additional support has been received from the Universities and Research Secretariat, Ministry of Business and Knowledge of the Catalan Government under the grant no. 2017‐SGR‐892. Marc Suárez‐Calvet received funding from the European Union's Horizon 2020 Research and Innovation Program under the Marie Sklodowska‐Curie action grant agreement No 752310, and currently receives funding from Instituto de Salud Carlos III (PI19/00155) and from the Spanish Ministry of Science, Innovation, and Universities (Juan de la Cierva Programme grant IJC2018‐037478‐I). Juan Domingo Gispert is supported by the Spanish Ministry of Science and Innovation (RYC‐2013‐13054). Oriol Grau‐Rivera is supported by the Spanish Ministry of Science, Innovation, and Universities (FJCI‐2017‐33437). ASV is the recipient of an Instituto de Salud Carlos III Miguel Servet II fellowship (CP II 17/00029). Eider M. Arenaza‐Urquijo is supported by the Spanish Ministry of Science, Innovation and Universities–Spanish State Research Agency (RYC2018‐026053‐I). Carolina Minguillon was supported by the Spanish Ministry of Economy and Competitiveness (grant n° IEDI‐2016‐00690).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Sánchez-Benavides G, Salvadó G, Arenaza-Urquijo EM, Grau-Rivera O, Suárez-Calvet M, Milà-Alomà M, et al. Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4. Alzheimers Dement (Amst). 2020 Nov 11; 12(1): e12127. DOI: 10.1002/dad2.12127
  • dc.identifier.doi http://dx.doi.org/10.1002/dad2.12127
  • dc.identifier.issn 2352-8729
  • dc.identifier.uri http://hdl.handle.net/10230/47574
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/752310
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/RYC2013‐13054
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/FJCI2017‐33437
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RYC2018‐026053‐I
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/IEDI‐2016‐00690
  • dc.rights Copyright © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
  • dc.subject.keyword Alzheimer's disease
  • dc.subject.keyword Amyloid
  • dc.subject.keyword Informant reports
  • dc.subject.keyword Preclinical
  • dc.subject.keyword Subjective cognitive decline
  • dc.title Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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