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Five-year quality of life in patients with high-risk localized prostate cancer treated with external beam radiotherapy alone versus external beam radiotherapy with high-dose-rate brachytherapy boost: a prospective multicenter study

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dc.contributor.author Martínez, Evelyn
dc.contributor.author Garin Boronat, Olatz, 1979-
dc.contributor.author Pardo Cladellas, Yolanda
dc.contributor.author Fernández, Pablo
dc.contributor.author Guix, Benjamin
dc.contributor.author Gutiérrez, Cristina
dc.contributor.author Boladeras, Ana
dc.contributor.author Ferrer, Ferran
dc.contributor.author Hernández, Tania
dc.contributor.author Ayala, Adriana
dc.contributor.author Egiguren, Mikel
dc.contributor.author Fernández, Gema
dc.contributor.author Muñoz, Víctor
dc.contributor.author Macías, Víctor
dc.contributor.author Pera, Joan
dc.contributor.author Pont Acuña, Àngels
dc.contributor.author Ferrer, Montserrat
dc.contributor.author Guedea, Ferrán
dc.date.accessioned 2021-05-07T07:06:26Z
dc.date.available 2021-05-07T07:06:26Z
dc.date.issued 2021
dc.identifier.citation Martínez E, Garin O, Pardo Y, Fernández P, Guix B, Gutiérrez C et al. Five-year quality of life in patients with high-risk localized prostate cancer treated with external beam radiotherapy alone versus external beam radiotherapy with high-dose-rate brachytherapy boost: a prospective multicenter study. J Contemp Brachytherapy 2021;13(1):1–11. DOI: 10.5114/jcb.2021.103580
dc.identifier.issn 1689-832X
dc.identifier.uri http://hdl.handle.net/10230/47349
dc.description.abstract Introduction: Brachytherapy (BT) and external beam radiation therapy (EBRT) are effective treatments for high-risk prostate cancer (PCa). However, the impact of these treatments on health-related quality of life (HRQL) remains unclear. In this study, we compared EBRT alone with EBRT plus a boost with high-dose rate (HDR)-BT to determine the impact on HRQL in patients with high-risk PCa. Material and methods: Prospective, multicenter study comparing patients with high-risk PCa treated with EBRT alone or EBRT + HDR-BT from 2004 to 2006. HRQL was assessed at baseline (pre-treatment) and periodically over the 5-year follow-up, using the SF-36 (v.2), EPIC, and FACT-G and FACT-P questionnaires. Results: A total of 129 patients were included in the study, of these, 41 received EBRT alone and 88 EBRT + HDR-BT. All patients received hormonotherapy. Baseline clinical characteristics were similar, except for a slightly higher mean number of comorbidities in the EBRT group. During follow-up, the only significant between-group difference was a greater worsening on EPIC hormonal domain in the EBRT alone group (p = 0.028). There were no significant differences in time and interaction of treatment in SF-36, and FACT-G and FACT-P questionnaires or EPIC urinary incontinence, urinary irritative-obstructive, and bowel and sexual domains over the 5-year follow-up. Oncological outcomes were similar in both groups. Conclusions: After five years of follow-up, EBRT alone or combined with HDR-BT boost had a similar impact on HRQL in patients with high-risk localized PCa. However, patients in the EBRT alone group experienced greater worsening of hormonal domain according to EPIC questionnaire.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Termedia Publishing
dc.relation.ispartof J Contemp Brachytherapy 2021;13(1):1–11
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.title Five-year quality of life in patients with high-risk localized prostate cancer treated with external beam radiotherapy alone versus external beam radiotherapy with high-dose-rate brachytherapy boost: a prospective multicenter study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.5114/jcb.2021.103580
dc.subject.keyword Quality of life
dc.subject.keyword Prostate cancer
dc.subject.keyword External beam radiotherapy
dc.subject.keyword High-dose-rate brachytherapy
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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