Five-year quality of life in patients with high-risk localized prostate cancer treated with external beam radiotherapy alone versus external beam radiotherapy with high-dose-rate brachytherapy boost: a prospective multicenter study

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  • dc.contributor.author Martínez, Evelyn
  • dc.contributor.author Garin Boronat, Olatz, 1979-
  • dc.contributor.author Pardo Cladellas, Yolanda
  • dc.contributor.author Fernández, Pablo
  • dc.contributor.author Guix, Benjamin
  • dc.contributor.author Gutiérrez, Cristina
  • dc.contributor.author Boladeras, Ana
  • dc.contributor.author Ferrer, Ferran
  • dc.contributor.author Hernández, Tania
  • dc.contributor.author Ayala, Adriana
  • dc.contributor.author Egiguren, Mikel
  • dc.contributor.author Fernández, Gema
  • dc.contributor.author Muñoz, Víctor
  • dc.contributor.author Macías, Víctor
  • dc.contributor.author Pera, Joan
  • dc.contributor.author Pont Acuña, Àngels
  • dc.contributor.author Ferrer Forés, Maria Montserrat
  • dc.contributor.author Guedea, Ferrán
  • dc.date.accessioned 2021-05-07T07:06:26Z
  • dc.date.available 2021-05-07T07:06:26Z
  • dc.date.issued 2021
  • dc.description.abstract Introduction: Brachytherapy (BT) and external beam radiation therapy (EBRT) are effective treatments for high-risk prostate cancer (PCa). However, the impact of these treatments on health-related quality of life (HRQL) remains unclear. In this study, we compared EBRT alone with EBRT plus a boost with high-dose rate (HDR)-BT to determine the impact on HRQL in patients with high-risk PCa. Material and methods: Prospective, multicenter study comparing patients with high-risk PCa treated with EBRT alone or EBRT + HDR-BT from 2004 to 2006. HRQL was assessed at baseline (pre-treatment) and periodically over the 5-year follow-up, using the SF-36 (v.2), EPIC, and FACT-G and FACT-P questionnaires. Results: A total of 129 patients were included in the study, of these, 41 received EBRT alone and 88 EBRT + HDR-BT. All patients received hormonotherapy. Baseline clinical characteristics were similar, except for a slightly higher mean number of comorbidities in the EBRT group. During follow-up, the only significant between-group difference was a greater worsening on EPIC hormonal domain in the EBRT alone group (p = 0.028). There were no significant differences in time and interaction of treatment in SF-36, and FACT-G and FACT-P questionnaires or EPIC urinary incontinence, urinary irritative-obstructive, and bowel and sexual domains over the 5-year follow-up. Oncological outcomes were similar in both groups. Conclusions: After five years of follow-up, EBRT alone or combined with HDR-BT boost had a similar impact on HRQL in patients with high-risk localized PCa. However, patients in the EBRT alone group experienced greater worsening of hormonal domain according to EPIC questionnaire.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Martínez E, Garin O, Pardo Y, Fernández P, Guix B, Gutiérrez C et al. Five-year quality of life in patients with high-risk localized prostate cancer treated with external beam radiotherapy alone versus external beam radiotherapy with high-dose-rate brachytherapy boost: a prospective multicenter study. J Contemp Brachytherapy 2021;13(1):1–11. DOI: 10.5114/jcb.2021.103580
  • dc.identifier.doi http://dx.doi.org/10.5114/jcb.2021.103580
  • dc.identifier.issn 1689-832X
  • dc.identifier.uri http://hdl.handle.net/10230/47349
  • dc.language.iso eng
  • dc.publisher Termedia Publishing
  • dc.relation.ispartof J Contemp Brachytherapy 2021;13(1):1–11
  • dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/
  • dc.subject.keyword Quality of life
  • dc.subject.keyword Prostate cancer
  • dc.subject.keyword External beam radiotherapy
  • dc.subject.keyword High-dose-rate brachytherapy
  • dc.title Five-year quality of life in patients with high-risk localized prostate cancer treated with external beam radiotherapy alone versus external beam radiotherapy with high-dose-rate brachytherapy boost: a prospective multicenter study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Departament de Medicina i Ciències de la Vida)
Articles (Hospital del Mar Research Institute)