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Diagnostic accuracy of pigmented labial macules by in vivo reflectance confocal microscopy and correlation among techniques

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dc.contributor.author Gómez-Martín, Ignacio
dc.contributor.author Collgros, Helena
dc.contributor.author Ferguson, Peter M.
dc.contributor.author Barreiro, Alicia
dc.contributor.author Guitera, Pascale
dc.contributor.author Andrades, Evelyn
dc.contributor.author Puig, Susana
dc.contributor.author Pujol Vallverdú, Ramon Maria
dc.contributor.author Barranco Sanz, Luis Carlos
dc.contributor.author Alòs, Llúcia
dc.contributor.author Segura Tigell, Sonia
dc.date.accessioned 2021-05-04T06:55:16Z
dc.date.available 2021-05-04T06:55:16Z
dc.date.issued 2021
dc.identifier.citation Gómez-Martín I, Collgros H, Ferguson PM, Barreiro A, Guitera P, Andrades-López E, et al. Diagnostic accuracy of pigmented labial macules by in vivo reflectance confocal microscopy and correlation among techniques. J Am Acad Dermatol. 2021 Nov;85(5):1151-1160. DOI: 10.1016/j.jaad.2020.02.067
dc.identifier.issn 0190-9622
dc.identifier.uri http://hdl.handle.net/10230/47300
dc.description.abstract Background: Pigmented labial macules (PLMs) are clinical, dermoscopic, and histopathologic challenges. Objective: To describe and evaluate the utility of reflectance confocal microscopy (RCM) in PLMs and to establish a correlation between dermoscopy, RCM, histopathology, and immunohistochemistry. Methods: Prospective study of PLMs from 4 tertiary referral dermatology centers. The study included 51 biopsy specimen-proven PLMs. Dermoscopic, RCM images, and histopathologic preparations were evaluated for malignant criteria. Diagnostic accuracy of RCM for melanoma diagnosis, RCM Lip Score previously reported, and κ values between techniques were calculated. Results: Included were 5 melanomas and 46 benign PLMs. Dermoscopically, melanomas exhibited more frequently ≥3 colors and ≥3 structures. With RCM, pagetoid spreading, epithelial disarray, continuous proliferation of atypical cells around papillae, nonhomogeneously distributed papillae, marked cellular atypia, and a higher number of dendritic cells per papillae were more frequent in melanomas. The RCM Lip Score was significantly higher in malignant lesions. Good κ values were observed in most of the evaluated features. A perfect sensitivity and specificity was obtained combining dermoscopy and RCM. Limitations: A low number of melanomas were obtained. Conclusions: RCM improves lip melanoma diagnosis, and the RCM Lip Score represents a useful tool for the evaluation of a PLM.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Journal of the American Academy of Dermatology. 2021 Nov;85(5):1151-1160
dc.rights © Elsevier http://dx.doi.org/10.1016/j.jaad.2020.02.067
dc.title Diagnostic accuracy of pigmented labial macules by in vivo reflectance confocal microscopy and correlation among techniques
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.jaad.2020.02.067
dc.subject.keyword Dermoscopy
dc.subject.keyword Labial macule
dc.subject.keyword Melanoma
dc.subject.keyword Melanotic macule
dc.subject.keyword Reflectance confocal microscopy
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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