Diagnostic accuracy of pigmented labial macules by in vivo reflectance confocal microscopy and correlation among techniques
Mostra el registre complet Registre parcial de l'ítem
- dc.contributor.author Gómez-Martín, Ignacio
- dc.contributor.author Collgros, Helena
- dc.contributor.author Ferguson, Peter M.
- dc.contributor.author Barreiro, Alicia
- dc.contributor.author Guitera, Pascale
- dc.contributor.author Andrades, Evelyn
- dc.contributor.author Puig, Susana
- dc.contributor.author Pujol Vallverdú, Ramon Maria
- dc.contributor.author Barranco Sanz, Luis Carlos
- dc.contributor.author Alòs, Llúcia
- dc.contributor.author Segura Tigell, Sonia
- dc.date.accessioned 2021-05-04T06:55:16Z
- dc.date.available 2021-05-04T06:55:16Z
- dc.date.issued 2021
- dc.description.abstract Background: Pigmented labial macules (PLMs) are clinical, dermoscopic, and histopathologic challenges. Objective: To describe and evaluate the utility of reflectance confocal microscopy (RCM) in PLMs and to establish a correlation between dermoscopy, RCM, histopathology, and immunohistochemistry. Methods: Prospective study of PLMs from 4 tertiary referral dermatology centers. The study included 51 biopsy specimen-proven PLMs. Dermoscopic, RCM images, and histopathologic preparations were evaluated for malignant criteria. Diagnostic accuracy of RCM for melanoma diagnosis, RCM Lip Score previously reported, and κ values between techniques were calculated. Results: Included were 5 melanomas and 46 benign PLMs. Dermoscopically, melanomas exhibited more frequently ≥3 colors and ≥3 structures. With RCM, pagetoid spreading, epithelial disarray, continuous proliferation of atypical cells around papillae, nonhomogeneously distributed papillae, marked cellular atypia, and a higher number of dendritic cells per papillae were more frequent in melanomas. The RCM Lip Score was significantly higher in malignant lesions. Good κ values were observed in most of the evaluated features. A perfect sensitivity and specificity was obtained combining dermoscopy and RCM. Limitations: A low number of melanomas were obtained. Conclusions: RCM improves lip melanoma diagnosis, and the RCM Lip Score represents a useful tool for the evaluation of a PLM.
- dc.format.mimetype application/pdf
- dc.identifier.citation Gómez-Martín I, Collgros H, Ferguson PM, Barreiro A, Guitera P, Andrades-López E, et al. Diagnostic accuracy of pigmented labial macules by in vivo reflectance confocal microscopy and correlation among techniques. J Am Acad Dermatol. 2021 Nov;85(5):1151-1160. DOI: 10.1016/j.jaad.2020.02.067
- dc.identifier.doi http://dx.doi.org/10.1016/j.jaad.2020.02.067
- dc.identifier.issn 0190-9622
- dc.identifier.uri http://hdl.handle.net/10230/47300
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Journal of the American Academy of Dermatology. 2021 Nov;85(5):1151-1160
- dc.rights © Elsevier http://dx.doi.org/10.1016/j.jaad.2020.02.067
- dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
- dc.subject.keyword Dermoscopy
- dc.subject.keyword Labial macule
- dc.subject.keyword Melanoma
- dc.subject.keyword Melanotic macule
- dc.subject.keyword Reflectance confocal microscopy
- dc.title Diagnostic accuracy of pigmented labial macules by in vivo reflectance confocal microscopy and correlation among techniques
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion