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Prevalence and pattern of cardiovascular magnetic resonance late gadolinium enhancement in highly trained endurance athletes

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dc.contributor.author Domenech Ximenos, Blanca
dc.contributor.author Sanz de la Garza, Maria
dc.contributor.author Prat Gonzàlez, Susanna
dc.contributor.author Sepúlveda-Martínez, Álvaro
dc.contributor.author Crispi Brillas, Fàtima
dc.contributor.author Duran-Fernandez, K.
dc.contributor.author Perea, Rosario J.
dc.contributor.author Bijnens, Bart
dc.contributor.author Sitges, Marta
dc.date.accessioned 2020-12-11T09:00:40Z
dc.date.available 2020-12-11T09:00:40Z
dc.date.issued 2020
dc.identifier.citation Domenech-Ximenos B, Sanz-de la Garza M, Prat-González S, Sepúlveda-Martínez A, Crispi F, Duran-Fernandez K, Perea RJ, Bijnens B, Sitges M. Prevalence and pattern of cardiovascular magnetic resonance late gadolinium enhancement in highly trained endurance athletes. J Cardiovasc Magn Reson. 2020 Sep 3;22:62. DOI: 10.1186/s12968-020-00660-w
dc.identifier.issn 1097-6647
dc.identifier.uri http://hdl.handle.net/10230/46002
dc.description.abstract Background Intensive endurance exercise may induce a broad spectrum of right ventricular (RV) adaptation/remodelling patterns. Late gadolinium enhancement (LGE) has also been described in cardiovascular magnetic resonance (CMR) of some endurance athletes and its clinical meaning remains controversial. Our aim was to characterize the features of contrast CMR and the observed patterns of the LGE distribution in a cohort of highly trained endurance athletes. Methods Ninety-three highly trained endurance athletes (> 12 h training/week at least during the last 5 years; 36 ± 6 years old; 53% male) and 72 age and gender-matched controls underwent a resting contrast CMR. In a subgroup of 28 athletes, T1 mapping was also performed. Results High endurance training load was associated with larger bi-ventricular and bi-atrial sizes and a slight reduction of biventricular ejection fraction, as compared to controls in both genders (p < 0.05). Focal LGE was significantly more prevalent in athletes than in healthy subjects (37.6% vs 2.8%; p < 0.001), with a typical pattern in the RV insertion points. In T1 mapping, those athletes who had focal LGE had higher extracellular volume (ECV) at the remote myocardium than those without (27 ± 2.2% vs 25.2 ± 2.1%; p < 0.05). Conclusions Highly trained endurance athletes showed a ten-fold increase in the prevalence of focal LGE as compared to control subjects, always confined to the hinge points. Additionally, those athletes with focal LGE demonstrated globally higher myocardial ECV values. This matrix remodelling and potential presence of myocardial fibrosis may be another feature of the athlete’s heart, of which the clinical and prognostic significance remains to be determined.
dc.description.sponsorship This work was partially funded by grants from AGAUR (M. Sanz-de la Garza, MD, PhD), Plan Nacional I. D, DelPrograma Estatal de Fomento De La Investigación Científica y Técnica de Excelencia, Subprograma De Generación Del Conocimiento, Ministerio de Economía y Competitividad 2013 (grant number DEP2013–44923-P).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof Journal of Cardiovascular Magnetic Resonance. 2020 Sep 3;22:62
dc.rights © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Prevalence and pattern of cardiovascular magnetic resonance late gadolinium enhancement in highly trained endurance athletes
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/s12968-020-00660-w
dc.subject.keyword Athletes
dc.subject.keyword Fibrosis
dc.subject.keyword Magnetic resonance imaging
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/DEP2013–44923-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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