dc.contributor.author |
Crespo Barrio, Marta |
dc.contributor.author |
Pérez-Sáez, María José |
dc.contributor.author |
Redondo Pachón, María Dolores |
dc.contributor.author |
Llinàs-Mallol, Laura |
dc.contributor.author |
Montero, Maria Milagro |
dc.contributor.author |
Villar García, Judit |
dc.contributor.author |
Arias Cabrales, Carlos Enrique |
dc.contributor.author |
Burballa Tàrrega, Carla, 1988- |
dc.contributor.author |
Vázquez, Susana |
dc.contributor.author |
Mir, Marisa |
dc.contributor.author |
Sierra Ochoa, Adriana |
dc.contributor.author |
Collado Nieto, Silvia |
dc.contributor.author |
Barrios Barrera, Clara |
dc.contributor.author |
Rodriguez García, Eva |
dc.contributor.author |
Sans Atxer, Laia |
dc.contributor.author |
Barbosa Puig, Francisco |
dc.contributor.author |
Cao Baduell, Higinio |
dc.contributor.author |
Arenas Jiménez, María Dolores |
dc.contributor.author |
Güerri Fernández, Roberto |
dc.contributor.author |
Horcajada Gallego, Juan Pablo |
dc.contributor.author |
Pascual Santos, Julio |
dc.date.accessioned |
2020-11-19T08:21:57Z |
dc.date.available |
2020-11-19T08:21:57Z |
dc.date.issued |
2020 |
dc.identifier.citation |
Crespo M, Pérez-Sáez MJ, Redondo-Pachón D, Llinàs-Mallol L, Montero MM, Villar-García J. et al. COVID-19 in elderly kidney transplant recipients. Am J Transplant. 2020 Oct; 20(10): 2883-89. DOI: 10.1111/ajt.16096 |
dc.identifier.issn |
1600-6135 |
dc.identifier.uri |
http://hdl.handle.net/10230/45810 |
dc.description.abstract |
The SARS-Cov-2 infection disease (COVID-19) pandemic has posed at risk the kidney transplant (KT) population, particularly the elderly recipients. From March 12 until April 4, 2020, we diagnosed COVID-19 in 16 of our 324 KT patients aged ≥65 years old (4.9%). Many of them had had contact with healthcare facilities in the month prior to infection. Median time of symptom onset to admission was 7 days. All presented with fever and all but one with pneumonia. Up to 33% showed renal graft dysfunction. At infection diagnosis, mTOR inhibitors or mycophenolate were withdrawn. Tacrolimus was withdrawn in 70%. The main treatment combination was hydroxychloroquine and azithromycin. A subset of patients was treated with anti-retroviral and tocilizumab. Short-term fatality rate was 50% at a median time since admission of 3 days. Those who died were more frequently obese, frail, and had underlying heart disease. Although a higher respiratory rate was observed at admission in nonsurvivors, symptoms at presentation were similar between both groups. Patients who died were more anemic, lymphopenic, and showed higher D-dimer, C-reactive protein, and IL-6 at their first tests. COVID-19 is frequent among the elderly KT population and associates a very early and high mortality rate. |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Wiley |
dc.rights |
This is the peer reviewed version of the following article: Crespo M, Pérez-Sáez MJ, Redondo-Pachón D, Llinàs-Mallol L, Montero MM, Villar-García J. et al. COVID-19 in elderly kidney transplant recipients. Am J Transplant. 2020 Oct; 20(10): 2883-89, which has been published in final form at http://dx.doi.org/10.1111/ajt.16096. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
dc.title |
COVID-19 in elderly kidney transplant recipients |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.1111/ajt.16096 |
dc.subject.keyword |
Clinical research/practice |
dc.subject.keyword |
Infection and infectious agents - viral |
dc.subject.keyword |
Kidney transplantation/nephrology |
dc.subject.keyword |
Patient survival |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/acceptedVersion |