COVID-19 in elderly kidney transplant recipients

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• dc.contributor.author Crespo Barrio, Marta
• dc.contributor.author Pérez-Sáez, María José
• dc.contributor.author Redondo Pachón, María Dolores
• dc.contributor.author Llinàs-Mallol, Laura
• dc.contributor.author Montero, Maria Milagro
• dc.contributor.author Villar García, Judit
• dc.contributor.author Arias Cabrales, Carlos Enrique
• dc.contributor.author Burballa Tàrrega, Carla, 1988-
• dc.contributor.author Vázquez, Susana
• dc.contributor.author Mir, Marisa
• dc.contributor.author Sierra Ochoa, Adriana
• dc.contributor.author Collado Nieto, Silvia
• dc.contributor.author Barrios Barrera, Clara
• dc.contributor.author Rodriguez García, Eva
• dc.contributor.author Sans Atxer, Laia
• dc.contributor.author Barbosa Puig, Francisco
• dc.contributor.author Cao Baduell, Higinio
• dc.contributor.author Arenas Jiménez, María Dolores
• dc.contributor.author Güerri Fernández, Roberto
• dc.contributor.author Horcajada Gallego, Juan Pablo
• dc.contributor.author Pascual Santos, Julio
• dc.date.accessioned 2020-11-19T08:21:57Z
• dc.date.available 2020-11-19T08:21:57Z
• dc.date.issued 2020
• dc.description.abstract The SARS-Cov-2 infection disease (COVID-19) pandemic has posed at risk the kidney transplant (KT) population, particularly the elderly recipients. From March 12 until April 4, 2020, we diagnosed COVID-19 in 16 of our 324 KT patients aged ≥65 years old (4.9%). Many of them had had contact with healthcare facilities in the month prior to infection. Median time of symptom onset to admission was 7 days. All presented with fever and all but one with pneumonia. Up to 33% showed renal graft dysfunction. At infection diagnosis, mTOR inhibitors or mycophenolate were withdrawn. Tacrolimus was withdrawn in 70%. The main treatment combination was hydroxychloroquine and azithromycin. A subset of patients was treated with anti-retroviral and tocilizumab. Short-term fatality rate was 50% at a median time since admission of 3 days. Those who died were more frequently obese, frail, and had underlying heart disease. Although a higher respiratory rate was observed at admission in nonsurvivors, symptoms at presentation were similar between both groups. Patients who died were more anemic, lymphopenic, and showed higher D-dimer, C-reactive protein, and IL-6 at their first tests. COVID-19 is frequent among the elderly KT population and associates a very early and high mortality rate.
• dc.format.mimetype application/pdf
• dc.identifier.citation Crespo M, Pérez-Sáez MJ, Redondo-Pachón D, Llinàs-Mallol L, Montero MM, Villar-García J. et al. COVID-19 in elderly kidney transplant recipients. Am J Transplant. 2020 Oct; 20(10): 2883-89. DOI: 10.1111/ajt.16096
• dc.identifier.doi http://dx.doi.org/10.1111/ajt.16096
• dc.identifier.issn 1600-6135
• dc.identifier.uri http://hdl.handle.net/10230/45810
• dc.language.iso eng
• dc.publisher Wiley
• dc.rights This is the peer reviewed version of the following article: Crespo M, Pérez-Sáez MJ, Redondo-Pachón D, Llinàs-Mallol L, Montero MM, Villar-García J. et al. COVID-19 in elderly kidney transplant recipients. Am J Transplant. 2020 Oct; 20(10): 2883-89, which has been published in final form at http://dx.doi.org/10.1111/ajt.16096. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Clinical research/practice
• dc.subject.keyword Infection and infectious agents - viral
• dc.subject.keyword Kidney transplantation/nephrology
• dc.subject.keyword Patient survival
• dc.title COVID-19 in elderly kidney transplant recipients
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion