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Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project

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dc.contributor.author Ranzani, Otavio
dc.contributor.author Milà, Carles
dc.contributor.author Sanchez, Margaux
dc.contributor.author Bhogadi, Santhi
dc.contributor.author Kulkarni, Bharati
dc.contributor.author Balakrishnan, Kalpana
dc.contributor.author Sambandam, Sankar
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Marshall, Julian D.
dc.contributor.author Kinra, Sanjay
dc.contributor.author Tonne, Cathryn
dc.date.accessioned 2020-05-05T07:30:03Z
dc.date.available 2020-05-05T07:30:03Z
dc.date.issued 2020
dc.identifier.citation Ranzani OT, Milà C, Sanchez M, Bhogadi S, Kulkarni B, Balakrishnan K, Sambandam S, Sunyer J, Marshall JD, Kinra S, Tonne C. Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project. Int J Epidemiol. 2020; 49(1):69-79. DOI: 10.1093/ije/dyz208
dc.identifier.issn 0300-5771
dc.identifier.uri http://hdl.handle.net/10230/44403
dc.description.abstract Background: Evidence linking ambient air pollution with atherosclerosis is lacking from low- and middle-income countries. Additionally, evidence regarding the association between household air pollution and atherosclerosis is limited. We evaluated the association between ambient fine particulate matter [particulate matter with an aerodynamic diameter of ≤2.5 µm (PM2.5)] and biomass fuel use on carotid intima-media thickness (CIMT), a surrogate of atherosclerosis, in India. Methods: We analysed the third follow-up of the Andhra Pradesh Children and Parent Study cohort (2010–2012), which recruited participants from 28 peri-urban villages. Our primary outcome was mean CIMT, measured using a standardized protocol. We estimated annual average PM2.5 outdoors at residence using land-use regression. Biomass cooking fuel was self-reported. We fitted a within-between linear-mixed model adjusting for potential confounders. Results: Among 3278 participants (48% women, mean age 38 years), mean PM2.5 was 32.7 [range 24.4–38.2] µg/m3, and 60% used biomass. After confounder adjustment, we observed positive associations between within-village variation in PM2.5 and CIMT in all participants [1.79%, 95% confidence interval (CI), −0.31 to 3.90 per 1  µg/m3 of PM2.5] and in men (2.98%, 95% CI, 0.23–5.72, per 1  µg/m3 of PM2.5). Use of biomass cooking fuel was associated with CIMT in all participants (1.60%, 95% CI, −0.46 to 3.65), especially in women with an unvented stove (6.14%, 95% CI, 1.40–10.89). The point-estimate for the PM2.5 association was larger in sub-groups with higher cardiometabolic risk profile. Conclusions: Ambient and household air pollution were positively associated with CIMT in a peri-urban population of India, although with limited precision for some estimates. We observed differences in the association between ambient and household air pollution and CIMT by gender.
dc.description.sponsorship This work was supported by the European Research Council (Grant Agreement 336167 for the CHAI Project) and the Wellcome Trust (Grant: 084674/Z for the third follow-up of the APCAPS). C.T. was funded through a Ramón y Cajal fellowship (RYC-2015–17402) awarded by the Spanish Ministry of Economy and Competitiveness.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Int J Epidemiol. 2020; 49(1):69-79
dc.rights © The Author(s) 2019. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/ije/dyz208
dc.subject.keyword Cardiovascular
dc.subject.keyword India
dc.subject.keyword Air pollution
dc.subject.keyword Atherosclerosis
dc.subject.keyword Particulate matter
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/336167
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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