Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project

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• dc.contributor.author Ranzani, Otavio
• dc.contributor.author Milà, Carles
• dc.contributor.author Sanchez, Margaux
• dc.contributor.author Bhogadi, Santhi
• dc.contributor.author Kulkarni, Bharati
• dc.contributor.author Balakrishnan, Kalpana
• dc.contributor.author Sambandam, Sankar
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Marshall, Julian D.
• dc.contributor.author Kinra, Sanjay
• dc.contributor.author Tonne, Cathryn
• dc.date.accessioned 2020-05-05T07:30:03Z
• dc.date.available 2020-05-05T07:30:03Z
• dc.date.issued 2020
• dc.description.abstract Background: Evidence linking ambient air pollution with atherosclerosis is lacking from low- and middle-income countries. Additionally, evidence regarding the association between household air pollution and atherosclerosis is limited. We evaluated the association between ambient fine particulate matter [particulate matter with an aerodynamic diameter of ≤2.5 µm (PM2.5)] and biomass fuel use on carotid intima-media thickness (CIMT), a surrogate of atherosclerosis, in India. Methods: We analysed the third follow-up of the Andhra Pradesh Children and Parent Study cohort (2010–2012), which recruited participants from 28 peri-urban villages. Our primary outcome was mean CIMT, measured using a standardized protocol. We estimated annual average PM2.5 outdoors at residence using land-use regression. Biomass cooking fuel was self-reported. We fitted a within-between linear-mixed model adjusting for potential confounders. Results: Among 3278 participants (48% women, mean age 38 years), mean PM2.5 was 32.7 [range 24.4–38.2] µg/m3, and 60% used biomass. After confounder adjustment, we observed positive associations between within-village variation in PM2.5 and CIMT in all participants [1.79%, 95% confidence interval (CI), −0.31 to 3.90 per 1  µg/m3 of PM2.5] and in men (2.98%, 95% CI, 0.23–5.72, per 1  µg/m3 of PM2.5). Use of biomass cooking fuel was associated with CIMT in all participants (1.60%, 95% CI, −0.46 to 3.65), especially in women with an unvented stove (6.14%, 95% CI, 1.40–10.89). The point-estimate for the PM2.5 association was larger in sub-groups with higher cardiometabolic risk profile. Conclusions: Ambient and household air pollution were positively associated with CIMT in a peri-urban population of India, although with limited precision for some estimates. We observed differences in the association between ambient and household air pollution and CIMT by gender.
• dc.description.sponsorship This work was supported by the European Research Council (Grant Agreement 336167 for the CHAI Project) and the Wellcome Trust (Grant: 084674/Z for the third follow-up of the APCAPS). C.T. was funded through a Ramón y Cajal fellowship (RYC-2015–17402) awarded by the Spanish Ministry of Economy and Competitiveness.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ranzani OT, Milà C, Sanchez M, Bhogadi S, Kulkarni B, Balakrishnan K, Sambandam S, Sunyer J, Marshall JD, Kinra S, Tonne C. Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project. Int J Epidemiol. 2020; 49(1):69-79. DOI: 10.1093/ije/dyz208
• dc.identifier.doi http://dx.doi.org/10.1093/ije/dyz208
• dc.identifier.issn 0300-5771
• dc.identifier.uri http://hdl.handle.net/10230/44403
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Int J Epidemiol. 2020; 49(1):69-79
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/336167
• dc.rights © The Author(s) 2019. Published by Oxford University Press on behalf of the International Epidemiological Association. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Cardiovascular
• dc.subject.keyword India
• dc.subject.keyword Air pollution
• dc.subject.keyword Atherosclerosis
• dc.subject.keyword Particulate matter
• dc.title Association between ambient and household air pollution with carotid intima-media thickness in peri-urban South India: CHAI-Project
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion