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Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts

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dc.contributor.author Fuertes, Elaine
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Vrijheid, Martine
dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author Kogevinas, Manolis
dc.contributor.author García Aymerich, Judith
dc.contributor.author Jacquemin Leonard, Bénédicte
dc.date.accessioned 2020-04-16T07:19:46Z
dc.date.available 2020-04-16T07:19:46Z
dc.date.issued 2020
dc.identifier.citation Fuertes E, Sunyer J, Gehring U, Porta D, Forastiere F, Cesaroni G et al. Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts. Environ Int. 2020; 136:105474. DOI: 10.1016/j.envint.2020.105474
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/44233
dc.description.abstract Background: Uncertainly continues to exist regarding the role of air pollution on pediatric asthma and allergic conditions, especially as air pollution levels have started to decrease in recent decades. Objective: We examined associations of long-term air pollution levels at the home address with pediatric eczema, rhinoconjunctivitis and asthma prevalences in five birth cohorts (BIB, EDEN, GASPII, RHEA and INMA) from seven areas in five European countries. Methods: Current eczema, rhinoconjunctivitis and asthma were assessed in children aged four (N = 6527) and eight years (N = 2489). A multi-morbidity outcome (≥2 conditions versus none) was also defined. Individual outdoor levels of nitrogen dioxide (NO2), nitrogen oxides, mass of particulate matter with an aerodynamic diameter <10 μm (PM10), 10–2.5 μm (PMcoarse) and <2.5 μm (PM2.5), and PM2.5 absorbance were assigned to the birth, four- and eight-year home addresses using highly defined spatial air pollution exposure models. Cohort-specific cross-sectional associations were assessed using logistic regression models adjusted for demographic and environmental covariates and combined in a random effects meta-analysis. Results: The overall prevalence of pediatric eczema, rhinoconjunctivitis and asthma at four years was 15.4%, 5.9% and 12.4%. We found no increase in the prevalence of these outcomes at four or eight years with increasing air pollution exposure. For example, the meta-analysis adjusted odds ratios (95% confidence intervals) for eczema, rhinoconjunctivitis and asthma at four years were 0.94 (0.81, 1.09), 0.90 (0.75, 1.09), and 0.91 (0.74, 1.11), respectively, per 10 μg/m3 increase in NO2 at the birth address, and 1.00 (0.81, 1.23), 0.70 (0.49, 1.00) and 0.88 (0.54, 1.45), respectively, per 5 μg/m3 increase in PM2.5 at the birth address. Discussion: In this large meta-analysis of five birth cohorts, we found no indication of adverse effects of long-term air pollution exposure on the prevalence of current pediatric eczema, rhinoconjunctivitis or asthma.
dc.description.sponsorship The research leading to these results was supported by the European Community’s Seventh Framework Program under grant agreement numbers 261357 (MeDALL) and 211250 (ESCAPE). Information about cohort-specific funding is available in the cohorts’ publications, and also, for INMA, in the Supplemental Material, Additional cohort funding sources section. The funding sources were not involved in the study design, in the collection, analysis and interpretation of data, the writing of the report and in the decision to submit the article for publication. ISGlobal is a member of CERCA Programme/Generalitat de Catalunya.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Int. 2020; 136:105474
dc.rights © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2020.105474
dc.subject.keyword Air pollution
dc.subject.keyword Asthma
dc.subject.keyword Birth cohort
dc.subject.keyword Eczema
dc.subject.keyword Pediatric
dc.subject.keyword Rhinoconjunctivitis
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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