Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts

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• dc.contributor.author Fuertes, Elaine
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Guxens Junyent, Mònica
• dc.contributor.author Kogevinas, Manolis
• dc.contributor.author García Aymerich, Judith
• dc.contributor.author Jacquemin Leonard, Bénédicte
• dc.date.accessioned 2020-04-16T07:19:46Z
• dc.date.available 2020-04-16T07:19:46Z
• dc.date.issued 2020
• dc.description.abstract Background: Uncertainly continues to exist regarding the role of air pollution on pediatric asthma and allergic conditions, especially as air pollution levels have started to decrease in recent decades. Objective: We examined associations of long-term air pollution levels at the home address with pediatric eczema, rhinoconjunctivitis and asthma prevalences in five birth cohorts (BIB, EDEN, GASPII, RHEA and INMA) from seven areas in five European countries. Methods: Current eczema, rhinoconjunctivitis and asthma were assessed in children aged four (N = 6527) and eight years (N = 2489). A multi-morbidity outcome (≥2 conditions versus none) was also defined. Individual outdoor levels of nitrogen dioxide (NO2), nitrogen oxides, mass of particulate matter with an aerodynamic diameter <10 μm (PM10), 10–2.5 μm (PMcoarse) and <2.5 μm (PM2.5), and PM2.5 absorbance were assigned to the birth, four- and eight-year home addresses using highly defined spatial air pollution exposure models. Cohort-specific cross-sectional associations were assessed using logistic regression models adjusted for demographic and environmental covariates and combined in a random effects meta-analysis. Results: The overall prevalence of pediatric eczema, rhinoconjunctivitis and asthma at four years was 15.4%, 5.9% and 12.4%. We found no increase in the prevalence of these outcomes at four or eight years with increasing air pollution exposure. For example, the meta-analysis adjusted odds ratios (95% confidence intervals) for eczema, rhinoconjunctivitis and asthma at four years were 0.94 (0.81, 1.09), 0.90 (0.75, 1.09), and 0.91 (0.74, 1.11), respectively, per 10 μg/m3 increase in NO2 at the birth address, and 1.00 (0.81, 1.23), 0.70 (0.49, 1.00) and 0.88 (0.54, 1.45), respectively, per 5 μg/m3 increase in PM2.5 at the birth address. Discussion: In this large meta-analysis of five birth cohorts, we found no indication of adverse effects of long-term air pollution exposure on the prevalence of current pediatric eczema, rhinoconjunctivitis or asthma.
• dc.description.sponsorship The research leading to these results was supported by the European Community’s Seventh Framework Program under grant agreement numbers 261357 (MeDALL) and 211250 (ESCAPE). Information about cohort-specific funding is available in the cohorts’ publications, and also, for INMA, in the Supplemental Material, Additional cohort funding sources section. The funding sources were not involved in the study design, in the collection, analysis and interpretation of data, the writing of the report and in the decision to submit the article for publication. ISGlobal is a member of CERCA Programme/Generalitat de Catalunya.
• dc.format.mimetype application/pdf
• dc.identifier.citation Fuertes E, Sunyer J, Gehring U, Porta D, Forastiere F, Cesaroni G et al. Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts. Environ Int. 2020; 136:105474. DOI: 10.1016/j.envint.2020.105474
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2020.105474
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/44233
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2020; 136:105474
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
• dc.rights © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
• dc.subject.keyword Air pollution
• dc.subject.keyword Asthma
• dc.subject.keyword Birth cohort
• dc.subject.keyword Eczema
• dc.subject.keyword Pediatric
• dc.subject.keyword Rhinoconjunctivitis
• dc.title Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion