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Three-dimensional regional bi-ventricular shape remodeling is associated with exercise capacity in endurance athletes

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dc.contributor.author Bernardino Perez, Gabriel
dc.contributor.author Sanz de la Garza, Maria
dc.contributor.author Domenech Ximenos, Blanca
dc.contributor.author Prat Gonzàlez, Susanna
dc.contributor.author Perea, Rosario J.
dc.contributor.author Blanco, Isabel
dc.contributor.author Burgos, Felip
dc.contributor.author Sepúlveda-Martínez, Álvaro
dc.contributor.author Rodríguez López, Mérida
dc.contributor.author Crispi Brillas, Fàtima
dc.contributor.author González Ballester, Miguel Ángel, 1973-
dc.contributor.author Craene, Mathieu de
dc.contributor.author Sitges, Marta
dc.contributor.author Bijnens, Bart
dc.date.accessioned 2020-03-27T14:56:13Z
dc.date.issued 2020
dc.identifier.citation Bernardino G, Sanz de la Garza M, Domenech-Ximenos B, Prat- Gonzàlez S, Perea RJ, Blanco I, Burgos F, Sepulveda-Martinez A, Rodriguez-Lopez M, Crispi F, Butakoff C, González Ballester MA, De Craene M, Sitges M, Bijnens B. Three-dimensional regional bi-ventricular shape remodeling is associated with exercise capacity in endurance athletes. Eur J Appl Physiol. 2020 Mar 4. DOI: 10.1007/s00421-020-04335-3
dc.identifier.issn 1069-9384
dc.identifier.uri http://hdl.handle.net/10230/44082
dc.description.abstract Aims: Endurance athletes develop cardiac remodeling to cope with increased cardiac output during exercise. This remodeling is both anatomical and functional and shows large interindividual variability. In this study, we quantify local geometric ven-tricular remodeling related to long-standing endurance training and assess its relationship with cardiovascular performance during exercise.Methods: We extracted 3D models of the biventricular shape from end-diastolic cine magnetic resonance images acquired from a cohort of 89 triathlon athletes and 77 healthy sedentary subjects. Additionally, the athletes underwent cardio-pulmonary exercise testing, together with an echocardiographic study at baseline and few minutes after maximal exercise. We used statistical shape analysis to identify regional bi-ventricular shape differences between athletes and non-athletes.Results: The ventricular shape was significantly different between athletes and controls (p < 1e−6). The observed regional remodeling in the right heart was mainly a shift of the right ventricle (RV) volume distribution towards the right ventricular infundibulum, increasing the overall right ventricular volume. In the left heart, there was an increment of left ventricular mass and a dilation of the left ventricle. Within athletes, the amount of such remodeling was independently associated to higher peak oxygen pulse (p < 0.001) and weakly with greater post-exercise RV free wall longitudinal strain (p = 0.03).Conclusions: We were able to identify specific bi-ventricular regional remodeling induced by long-lasting endurance training. The amount of remodeling was associated with better cardiopulmonary performance during an exercise test.
dc.description.sponsorship This study was partially supported by the Spanish Ministry of Economy and Competitiveness (Grant DEP2013-44923-P, TIN2014-52923-R; Maria de Maeztu Units of Excellence Programme—MDM-2015-0502), el Fondo Europeo de Desarrollo Regional (FEDER), the European Union under the Horizon 2020 Programme for Research, Innovation (Grant agreement No. 642676 CardioFunXion) and Erasmus+Programme (Framework Agreement number: 2013-0040), “la Caixa” Foundation (LCF/PR/GN14/10270005, LCF/PR/GN18/10310003), Instituto de Salud Carlos III (PI14/00226, PI15/00130, PI17/00675) integrated in the “Plan Nacional I+D+I” and AGAUR 2017 SGR Grant no. 1531.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof European Journal of Applied Physiology . 2020 Mar 4.
dc.rights © Springer The final publication is available at Springer via https://doi.org/10.1007/s00421-020-04335-3
dc.title Three-dimensional regional bi-ventricular shape remodeling is associated with exercise capacity in endurance athletes
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s00421-020-04335-3
dc.subject.keyword Exercise physiology
dc.subject.keyword Athlete’s heart
dc.subject.keyword Cardiac remodeling
dc.subject.keyword Statistical shape analysis
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642676
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/DEP2013-44923-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2014-52923-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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