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Modularity, criticality, and evolvability of a developmental gene regulatory network

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dc.contributor.author Verd Fernández, Berta, 1984-
dc.contributor.author Monk, Nicholas A.
dc.contributor.author Jaeger, Johannes, 1973-
dc.date.accessioned 2020-03-19T06:59:27Z
dc.date.available 2020-03-19T06:59:27Z
dc.date.issued 2019
dc.identifier.citation Verd B, Monk NA, Jaeger J. Modularity, criticality, and evolvability of a developmental gene regulatory network. Elife. 2019; 8. pii: e42832. DOI: 10.7554/eLife.42832
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10230/43945
dc.description.abstract The existence of discrete phenotypic traits suggests that the complex regulatory processes which produce them are functionally modular. These processes are usually represented by networks. Only modular networks can be partitioned into intelligible subcircuits able to evolve relatively independently. Traditionally, functional modularity is approximated by detection of modularity in network structure. However, the correlation between structure and function is loose. Many regulatory networks exhibit modular behaviour without structural modularity. Here we partition an experimentally tractable regulatory network-the gap gene system of dipteran insects-using an alternative approach. We show that this system, although not structurally modular, is composed of dynamical modules driving different aspects of whole-network behaviour. All these subcircuits share the same regulatory structure, but differ in components and sensitivity to regulatory interactions. Some subcircuits are in a state of criticality, while others are not, which explains the observed differential evolvability of the various expression features in the system.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher eLife
dc.relation.ispartof Elife. 2019; 8. pii: e42832
dc.rights © 2019, Verd et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Modularity, criticality, and evolvability of a developmental gene regulatory network
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.7554/eLife.42832
dc.subject.keyword D. melanogaster
dc.subject.keyword Modularity
dc.subject.keyword Computational biology
dc.subject.keyword Criticality
dc.subject.keyword Developmental biology
dc.subject.keyword Developmental gene regulatory networks
dc.subject.keyword Dynamical systems
dc.subject.keyword Evolvability
dc.subject.keyword Systems biology
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-10184
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-33775
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV-2012-0208
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/289434
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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