Modularity, criticality, and evolvability of a developmental gene regulatory network
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- dc.contributor.author Verd Fernández, Berta, 1984-
- dc.contributor.author Monk, Nicholas A.
- dc.contributor.author Jaeger, Johannes, 1973-
- dc.date.accessioned 2020-03-19T06:59:27Z
- dc.date.available 2020-03-19T06:59:27Z
- dc.date.issued 2019
- dc.description.abstract The existence of discrete phenotypic traits suggests that the complex regulatory processes which produce them are functionally modular. These processes are usually represented by networks. Only modular networks can be partitioned into intelligible subcircuits able to evolve relatively independently. Traditionally, functional modularity is approximated by detection of modularity in network structure. However, the correlation between structure and function is loose. Many regulatory networks exhibit modular behaviour without structural modularity. Here we partition an experimentally tractable regulatory network-the gap gene system of dipteran insects-using an alternative approach. We show that this system, although not structurally modular, is composed of dynamical modules driving different aspects of whole-network behaviour. All these subcircuits share the same regulatory structure, but differ in components and sensitivity to regulatory interactions. Some subcircuits are in a state of criticality, while others are not, which explains the observed differential evolvability of the various expression features in the system.
- dc.format.mimetype application/pdf
- dc.identifier.citation Verd B, Monk NA, Jaeger J. Modularity, criticality, and evolvability of a developmental gene regulatory network. Elife. 2019; 8. pii: e42832. DOI: 10.7554/eLife.42832
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.42832
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/43945
- dc.language.iso eng
- dc.publisher eLife
- dc.relation.ispartof Elife. 2019; 8. pii: e42832
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2009-10184
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-33775
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV-2012-0208
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/289434
- dc.rights © 2019, Verd et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword D. melanogaster
- dc.subject.keyword Modularity
- dc.subject.keyword Computational biology
- dc.subject.keyword Criticality
- dc.subject.keyword Developmental biology
- dc.subject.keyword Developmental gene regulatory networks
- dc.subject.keyword Dynamical systems
- dc.subject.keyword Evolvability
- dc.subject.keyword Systems biology
- dc.title Modularity, criticality, and evolvability of a developmental gene regulatory network
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion