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A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial

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dc.contributor.author Farràs Mañé, Marta
dc.contributor.author Arranz, Sara
dc.contributor.author Carrión, Sílvia
dc.contributor.author Subirana Cachinero, Isaac
dc.contributor.author Muñoz-Aguayo, D.
dc.contributor.author Blanchart, Gemma
dc.contributor.author Kool, Marjon
dc.contributor.author Solà, Rosa
dc.contributor.author Motilva, Maria-José
dc.contributor.author Escolà-Gil, Joan Carles
dc.contributor.author Rubió, Laura
dc.contributor.author Fernández-Castillejo, Sara
dc.contributor.author Pedret, Anna
dc.contributor.author Estruch, Ramón
dc.contributor.author Covas Planells, Maria Isabel
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Hernáez, Álvaro
dc.contributor.author Castañer, Olga
dc.date.accessioned 2020-03-16T08:58:27Z
dc.date.available 2020-03-16T08:58:27Z
dc.date.issued 2019
dc.identifier.citation Farràs M, Arranz S, Carrión S, Subirana I, Muñoz-Aguayo D, Blanchart G. et al. A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial. Nutrients. 2019 Jul 26; 11(8):1732. DOI: 10.3390/nu11081732
dc.identifier.issn 2072-6643
dc.identifier.uri http://hdl.handle.net/10230/43896
dc.description.abstract The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg); (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg; FVOOT), and; (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of CYP27A1 (P = 0.041 and P = 0.053, versus baseline and the control intervention, respectively), CAV1 (P = 0.070, versus the control intervention), and LXRβ, RXRα, and PPARβ/δ (P = 0.005, P = 0.005, and P = 0.038, respectively, relative to the baseline). The consumption of a functional VOO enriched with olive oil and thyme PCs enhanced the expression of key cholesterol efflux regulators, such as CYP27A1 and nuclear receptor-related genes.
dc.description.sponsorship This research was funded by: the Spanish Ministry of Economy and Competitiveness (AGL2009-13517-C03-01, AGL2012-40144-C03-01), the Instituto de Salud Carlos III (CB06/03/0028, CB07/08/0016, CD17/00122, CD17/00233, and JR17/00022), FEDER funds (CB06/03), and the Agència de Gestió d’Ajuts Universitaris i de Recerca (2014-SGR-240, 2017-SGR-522).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/nu11081732
dc.subject.keyword HDL cholesterol
dc.subject.keyword Cholesterol efflux
dc.subject.keyword Functional virgin olive oil
dc.subject.keyword Olive oil phenolic compounds
dc.subject.keyword Thyme phenolic compounds
dc.subject.keyword Transcriptomics
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13517-C03-01
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2012-40144-C03-01
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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