A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial

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• dc.contributor.author Farràs Mañé, Marta
• dc.contributor.author Arranz, Sara
• dc.contributor.author Carrión, Sílvia
• dc.contributor.author Subirana Cachinero, Isaac
• dc.contributor.author Muñoz-Aguayo, D.
• dc.contributor.author Blanchart, Gemma
• dc.contributor.author Kool, Marjon
• dc.contributor.author Solà, Rosa
• dc.contributor.author Motilva, Maria-José
• dc.contributor.author Escolà-Gil, Joan Carles
• dc.contributor.author Rubió, Laura
• dc.contributor.author Fernández-Castillejo, Sara
• dc.contributor.author Pedret, Anna
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Covas Planells, Maria Isabel
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Hernáez, Álvaro
• dc.contributor.author Castañer, Olga
• dc.date.accessioned 2020-03-16T08:58:27Z
• dc.date.available 2020-03-16T08:58:27Z
• dc.date.issued 2019
• dc.description.abstract The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg); (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg; FVOOT), and; (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of CYP27A1 (P = 0.041 and P = 0.053, versus baseline and the control intervention, respectively), CAV1 (P = 0.070, versus the control intervention), and LXRβ, RXRα, and PPARβ/δ (P = 0.005, P = 0.005, and P = 0.038, respectively, relative to the baseline). The consumption of a functional VOO enriched with olive oil and thyme PCs enhanced the expression of key cholesterol efflux regulators, such as CYP27A1 and nuclear receptor-related genes.
• dc.description.sponsorship This research was funded by: the Spanish Ministry of Economy and Competitiveness (AGL2009-13517-C03-01, AGL2012-40144-C03-01), the Instituto de Salud Carlos III (CB06/03/0028, CB07/08/0016, CD17/00122, CD17/00233, and JR17/00022), FEDER funds (CB06/03), and the Agència de Gestió d’Ajuts Universitaris i de Recerca (2014-SGR-240, 2017-SGR-522).
• dc.format.mimetype application/pdf
• dc.identifier.citation Farràs M, Arranz S, Carrión S, Subirana I, Muñoz-Aguayo D, Blanchart G. et al. A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial. Nutrients. 2019 Jul 26; 11(8):1732. DOI: 10.3390/nu11081732
• dc.identifier.doi http://dx.doi.org/10.3390/nu11081732
• dc.identifier.issn 2072-6643
• dc.identifier.uri http://hdl.handle.net/10230/43896
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2009-13517-C03-01
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2012-40144-C03-01
• dc.rights Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword HDL cholesterol
• dc.subject.keyword Cholesterol efflux
• dc.subject.keyword Functional virgin olive oil
• dc.subject.keyword Olive oil phenolic compounds
• dc.subject.keyword Thyme phenolic compounds
• dc.subject.keyword Transcriptomics
• dc.title A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion