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Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder

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dc.contributor.author Petrus, Clara
dc.contributor.author Marcos-Vidal, Luis
dc.contributor.author Martínez-García, Magdalena
dc.contributor.author Picado, Marisol
dc.contributor.author Ramos-Quiroga; Josep Antoni
dc.contributor.author Richarte, Vanesa
dc.contributor.author Castellanos, Francisco X.
dc.contributor.author Sepulcre, Jorge
dc.contributor.author Desco, Manuel
dc.contributor.author Vilarroya, Óscar
dc.contributor.author Carmona, Susanna
dc.date.accessioned 2020-01-27T07:52:06Z
dc.date.issued 2019
dc.identifier.citation Pretus C, Marcos-Vidal L, Martínez-García M, Picado M, Ramos-Quiroga JA, Richarte V. et al. Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder. Hum Brain Mapp. 2019 Nov 1;40(16):4645-4656. DOI 10.1002/hbm.24727
dc.identifier.issn 1065-9471
dc.identifier.uri http://hdl.handle.net/10230/43414
dc.description.abstract Neuroimaging studies indicate that children with attention-deficit/hyperactivity disorder (ADHD) present alterations in several functional networks of the sensation-to-cognition spectrum. These alterations include functional overconnectivity within sensory regions and underconnectivity between sensory regions and neural hubs supporting higher order cognitive functions. Today, it is unknown whether this same pattern of alterations persists in adult patients with ADHD who had never been medicated for their condition. The aim of the present study was to assess whether medication-naïve adults with ADHD presented alterations in functional networks of the sensation-to-cognition spectrum. Thirty-one medication-naïve adults with ADHD and twenty-two healthy adults underwent resting-state functional magnetic resonance imaging (rs-fMRI). Stepwise functional connectivity (SFC) was used to characterize the pattern of functional connectivity between sensory seed regions and the rest of the brain at direct, short, intermediate, and long functional connectivity distances, thus covering the continuum from the sensory input to the neural hubs supporting higher order cognitive functions. As compared to controls, adults with ADHD presented increased SFC degree within primary sensory regions and decreased SFC degree between sensory seeds and higher order integration nodes. In addition, they exhibited decreased connectivity degree between sensory seeds and regions of the default-mode network. Consistently, the higher the score in clinical severity scales the lower connectivity degree between seed regions and the default mode network.
dc.description.sponsorship The authors thank the volunteers who generously contributed to this research. This work was supported by the Ministerio de Economía y Competitividad research grant (SAF2012‐32362) and the Instituto de Salud Carlos III (Miguel Servet Type I (CP16/00096), AES Grant (PI17/00064), and P‐FIS Grant (FI18/00255)).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights This is the peer reviewed version of the following article: Pretus C, Marcos-Vidal L, Martínez-García M, Picado M, Ramos-Quiroga JA, Richarte V. et al. Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder. Hum Brain Mapp. 2019 Nov 1;40(16):4645-4656. DOI 10.1002/hbm.24727, which has been published in final form at http://dx.doi.org/10.1002/hbm.24727. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
dc.title Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/hbm.24727
dc.subject.keyword ADHD
dc.subject.keyword Adult ADHD
dc.subject.keyword Default mode network
dc.subject.keyword Resting-state fMRI
dc.subject.keyword Stepwise functional connectivity
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012‐32362
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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