Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder

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• dc.contributor.author Petrus, Clara
• dc.contributor.author Marcos-Vidal, Luis
• dc.contributor.author Martínez-García, Magdalena
• dc.contributor.author Picado, Marisol
• dc.contributor.author Ramos-Quiroga; Josep Antoni
• dc.contributor.author Richarte, Vanesa
• dc.contributor.author Castellanos, Francisco X.
• dc.contributor.author Sepulcre, Jorge
• dc.contributor.author Desco, Manuel
• dc.contributor.author Vilarroya, Óscar
• dc.contributor.author Carmona, Susanna
• dc.date.accessioned 2020-01-27T07:52:06Z
• dc.date.issued 2019
• dc.description.abstract Neuroimaging studies indicate that children with attention-deficit/hyperactivity disorder (ADHD) present alterations in several functional networks of the sensation-to-cognition spectrum. These alterations include functional overconnectivity within sensory regions and underconnectivity between sensory regions and neural hubs supporting higher order cognitive functions. Today, it is unknown whether this same pattern of alterations persists in adult patients with ADHD who had never been medicated for their condition. The aim of the present study was to assess whether medication-naïve adults with ADHD presented alterations in functional networks of the sensation-to-cognition spectrum. Thirty-one medication-naïve adults with ADHD and twenty-two healthy adults underwent resting-state functional magnetic resonance imaging (rs-fMRI). Stepwise functional connectivity (SFC) was used to characterize the pattern of functional connectivity between sensory seed regions and the rest of the brain at direct, short, intermediate, and long functional connectivity distances, thus covering the continuum from the sensory input to the neural hubs supporting higher order cognitive functions. As compared to controls, adults with ADHD presented increased SFC degree within primary sensory regions and decreased SFC degree between sensory seeds and higher order integration nodes. In addition, they exhibited decreased connectivity degree between sensory seeds and regions of the default-mode network. Consistently, the higher the score in clinical severity scales the lower connectivity degree between seed regions and the default mode network.
• dc.description.sponsorship The authors thank the volunteers who generously contributed to this research. This work was supported by the Ministerio de Economía y Competitividad research grant (SAF2012‐32362) and the Instituto de Salud Carlos III (Miguel Servet Type I (CP16/00096), AES Grant (PI17/00064), and P‐FIS Grant (FI18/00255)).
• dc.format.mimetype application/pdf
• dc.identifier.citation Pretus C, Marcos-Vidal L, Martínez-García M, Picado M, Ramos-Quiroga JA, Richarte V. et al. Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder. Hum Brain Mapp. 2019 Nov 1;40(16):4645-4656. DOI 10.1002/hbm.24727
• dc.identifier.doi http://dx.doi.org/10.1002/hbm.24727
• dc.identifier.issn 1065-9471
• dc.identifier.uri http://hdl.handle.net/10230/43414
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012‐32362
• dc.rights This is the peer reviewed version of the following article: Pretus C, Marcos-Vidal L, Martínez-García M, Picado M, Ramos-Quiroga JA, Richarte V. et al. Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder. Hum Brain Mapp. 2019 Nov 1;40(16):4645-4656. DOI 10.1002/hbm.24727, which has been published in final form at http://dx.doi.org/10.1002/hbm.24727. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword ADHD
• dc.subject.keyword Adult ADHD
• dc.subject.keyword Default mode network
• dc.subject.keyword Resting-state fMRI
• dc.subject.keyword Stepwise functional connectivity
• dc.title Stepwise functional connectivity reveals altered sensory-multimodal integration in medication-naïve adults with attention deficit hyperactivity disorder
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion